Human cytomegalovirus-Induced Interleukin-10 production promotes the proliferation of Mycobacterium massiliense in macrophages

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Title
Human cytomegalovirus-Induced Interleukin-10 production promotes the proliferation of Mycobacterium massiliense in macrophages
Author(s)
H Quan; J Kim; Y R N a; J H Kim; B J Kim; B J Kim; Jung Joo Hong; E S Hwang; S H Seok
Bibliographic Citation
Frontiers in Immunology, vol. 11, pp. 518605-518605
Publication Year
2020
Abstract
Human cytomegalovirus (HCMV) exploits the interleukin-10 (IL-10) pathway as a part of its infection cycle through the manipulation of the host IL-10 signaling cascade. Based on its immunomodulatory nature, HCMV attenuates the host immune response and facilitates the progression of co-infection with other pathogens in an immune-competent host. To investigate the impact of HCMV infection on the burden of non-tuberculous mycobacteria (NTM), whose prevalence is growing rapidly worldwide, macrophages were infected with HCMV and further challenged with Mycobacterium massiliense in vitro. The results showed that HCMV infection significantly increased host IL-10 synthesis and promoted the proliferation of M. massiliense in an IL-10-dependent manner. Transcriptomic analysis revealed that HCMV infection dampened the regulatory pathways of interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin-1 (IL-1), consequently abrogating the immune responses to M. massiliense coinfection in macrophages. These findings provide a mechanistic basis of how HCMV infection may facilitate the development of pathogenic NTM co-infection by upregulating IL-10 expression.
Keyword
human cytomegalovirusmacrophageMycobacterium massilienseinterleukin-10non-tuberculous mycobacteria
ISSN
1664-3224
Publisher
Frontiers Media Sa
DOI
http://dx.doi.org/10.3389/fimmu.2020.518605
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
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