Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques

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Title
Transient lymphopenia and interstitial pneumonia with endotheliitis in SARS-CoV-2-infected macaques
Author(s)
Bon Sang KooHanseul Oh; Green Kim; Eun Ha Hwang; Hoyin Jung; Young Jeon LeePhilyong Kang; J H Park; Choong-Min RyuJung Joo Hong
Bibliographic Citation
Journal of Infectious Diseases, vol. 222, pp. 1596-1600
Publication Year
2020
Abstract
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
Keyword
macaqueslymphopeniapneumoniaSARS-CoV-2
ISSN
0022-1899
Publisher
Oxford Univ Press
DOI
http://dx.doi.org/10.1093/infdis/jiaa486
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > National Primate Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > Futuristic Animal Resource & Research Center > 1. Journal Articles
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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