Jaceosidin ameliorates insulin resistance and kidney dysfunction by enhancing insulin receptor signaling and the antioxidant defense system in type 2 diabetic mice

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Title
Jaceosidin ameliorates insulin resistance and kidney dysfunction by enhancing insulin receptor signaling and the antioxidant defense system in type 2 diabetic mice
Author(s)
E Park; K Hong; Byoung-Mog Kwon; Y Kim; J H Kim
Bibliographic Citation
Journal of Medicinal Food, vol. 23, no. 10, pp. 1083-1092
Publication Year
2020
Abstract
Emerging evidence has shown that flavonoids extracted from Artemisia have beneficial effects on metabolic disorders. However, whether and how jaceosidin ameliorates insulin resistance and diabetic nephropathy in type 2 diabetes mellitus is largely unknown. For 8 weeks, db/db diabetic mice were fed with or without jaceosidin. Oral jaceosidin supplementation reduced fasting blood glucose levels and insulin resistance through the upregulation of insulin receptor downstream pathways in the liver and skeletal muscles. While jaceosidin did not noticeably alter kidney filtration function, this dietary intervention contributed to attenuating the accumulation of advanced glycation end products in diabetic kidneys. The levels of VEGF-a (vascular endothelial growth factor-a) proteins in the diabetic kidneys were markedly diminished by jaceosidin treatments, which increased the expression and activity of Cu (copper) and Zn-SOD (zinc-superoxide dismutase). Therefore, it is suggested that jaceosidin supplementation elicits antidiabetic effects and treats diabetic nephropathy by augmenting insulin signaling, suppressing fibrosis, and enhancing antioxidant activity.
Keyword
Aktdiabetic nephropathyglucose transporterjaceosidinsuperoxide dismutase
ISSN
1096-620X
Publisher
Mary Ann Liebert, Inc
DOI
http://dx.doi.org/10.1089/jmf.2020.4739
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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