MAM domain containing 2 is a potential breast cancer biomarker that exhibits tumour-suppressive activity

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Title
MAM domain containing 2 is a potential breast cancer biomarker that exhibits tumour-suppressive activity
Author(s)
H Lee; B C Park; Jong Soon Kang; Y Chheon; S Lee; P J Maeng
Bibliographic Citation
Cell Proliferation, vol. 53, no. 9, pp. e12883-e12883
Publication Year
2020
Abstract
Objectives : The aim of this study was to discover new potential biomarkers of breast cancer and investigate their cellular functions. Materials and methods : We analysed the gene expression profiles of matched pairs of breast tumour and normal tissues from 24 breast cancer patients. Tetracycline-inducible MAMDC2 expression system was established and used to evaluate cell proliferation in vitro and in vivo. MAMDC2-mediated signalling was determined using immunoblot analysis. Results : We identified MAMDC2 as a down-regulated gene showing significant prognostic capability. Overexpression of MAMDC2 or treatment with MAMDC2-containing culture medium significantly inhibited the cell proliferation of T-47D cells. Furthermore, MAMDC2 expression reduced in vivo growth of T-47D xenograft tumours. MAMDC2 may exert its growth-inhibitory functions by attenuating the MAPK signalling pathway. Conclusion : We report that MAMDC2 has a tumour-suppressive role and, as a secretory protein, it might be useful as a biomarker for breast cancer treatment.
Keyword
BiomarkersBreast cancerCell proliferationTumour suppressor
ISSN
0960-7722
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/cpr.12883
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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