Emergence of third-generation cephalosporin-resistant Morganella morganii in a captive breeding dolphin in South Korea

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Title
Emergence of third-generation cephalosporin-resistant Morganella morganii in a captive breeding dolphin in South Korea
Author(s)
Seon Young Park; K Lee; Y Cho; Sera Lim; Hyemin Kwon; J E Han; Ji Hyung Kim
Bibliographic Citation
Animals, vol. 10, pp. 2052-2052
Publication Year
2020
Abstract
The emergence of antimicrobial resistant (AMR) strains of Morganella morganii is increasingly being recognized. Recently, we reported a fatal M. morganii infection in a captive bottlenose dolphin (Tursiops truncatus) bred at a dolphinarium in South Korea. According to our subsequent investigations, the isolated M. morganii strain KC-Tt-01 exhibited extensive resistance to third-generation cephalosporins which have not been reported in animals. Therefore, in the present study, the genome of strain KC-Tt-01 was sequenced, and putative virulence and AMR genes were investigated. The strain had virulence and AMR genes similar to those of other M. morganii strains, including a strain that causes human sepsis. An amino-acid substitution detected at the 86th residue (Arg to Cys) of the protein encoded by ampR might explain the extended resistance to third-generation cephalosporins. These results indicate that the AMR M. morganii strain isolated from the captive dolphin has the potential to cause fatal zoonotic infections with antibiotic treatment failure due to extended drug resistance, and therefore, the management of antibiotic use and monitoring of the emergence of AMR bacteria are urgently needed in captive cetaceans for their health and conservation.
Keyword
marine mammal healthcetaceanantimicrobial resistanceampRzoonotic infection
ISSN
2076-2615
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ani10112052
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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