Highly Oxygenated Angucycline From Streptomyces Sp. KCB15JA014

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Title
Highly Oxygenated Angucycline From Streptomyces Sp. KCB15JA014
Author(s)
Gil Soo Kim; G J Kim; Byeongsan Lee; T H Oh; Mincheol Kwon; Jung-Sook LeeJun-Pil Jang; H Choi; Sung-Kyun KoYoung-Soo HongJae-Hyuk JangJong Seog Ahn
Bibliographic Citation
Journal of Antibiotics, vol. 73, no. 12, pp. 859-862
Publication Year
2020
Abstract
LC/MS-based chemical screening of culture extract led to a new highly oxygenated angucycline derivative, grecocycline D (1), from Streptomyces sp. KCB15JA014, isolated from a soil sample of Oedolgae in Jeju Island, Korea. The planar structure was determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as HRESIMS and comparison with data from the literature. A relative and absolute configuration of 1 was assigned by ROESY experiment and electronic circular dichroism calculation. Compound 1 showed weak inhibitory activity against indoleamine 2,3-dioxygenase.
ISSN
0021-8820
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/s41429-020-0348-8
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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