Two new meroterpenes with activity against diacylglycerol acyltransferase from seeds of Psoralea corylifolia

Abstract

Two new meroterpenes, 7β, 13β-Psoracorylifol B (1) and 7β, 8α-Psoracorylifol D (3) together with eight known compounds (2, 4 - 10) were isolated from the seeds of Psoralea corylifolia L. They were identified by a series of spectroscopic methods to determine their structures and all the compounds were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 1-5 and 10 showed moderate inhibitory activity against DGAT1 with IC50 values ranging from 67.1 ± 1.3？130.4 ± 1.2 μM, compounds 1-2 showed weak inhibitory activity against DGAT2 with IC50 values 132.9 ± 1.1 and 134.2 ± 1.2 μM.