The anti-inflammatory effect of Trichilia martiana C. DC. in the lipopolysaccharide-stimulated inflammatory response in macrophages and airway epithelial cells and in LPS-challenged mice

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dc.contributor.authorJi Won Park-
dc.contributor.authorHyung Won Ryu-
dc.contributor.authorHye In Ahn-
dc.contributor.authorJae-Hong Min-
dc.contributor.authorSeong-Man Kim-
dc.contributor.authorMin-Gu Kim-
dc.contributor.authorOk-Kyoung Kwon-
dc.contributor.authorDaseul Hwang-
dc.contributor.authorSoo Yong Kim-
dc.contributor.authorSangho Choi-
dc.contributor.authorN Zamora-
dc.contributor.authorK Rosales-
dc.contributor.authorSei-Ryang Oh-
dc.contributor.authorJae-Won Lee-
dc.contributor.authorKyung Seop Ahn-
dc.date.accessioned2020-11-17T09:24:53Z-
dc.date.available2020-11-17T09:24:53Z-
dc.date.issued2020-
dc.identifier.issn10177825-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/23501-
dc.description.abstractA number of species of the genus Trichilia (Meliaceae) exhibit anti-inflammatory effects. However, the effect of Trichilia martiana C. DC. (TM) on lipopolysaccharide (LPS)-induced inflammation has not, to the best of our knowledge, yet been determined. Therefore, in the present study, the anti-inflammatory effect of TM on LPS-stimulated RAW264.7 macrophages was evaluated. The ethanol extract of TM (TMEE) significantly inhibited LPS-induced nitric oxide (NO), prostaglandin 2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). TMEE also reduced the levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6. The upregulation of mitogen-activated protein kinases (MAPKs) and NF-κB activation was revealed to be downregulated following TMEE pretreatment. Furthermore, TMEE was indicated to lead to the nucleus translocation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and the expression of heme oxygenase-1 (HO-1). In H292 airway epithelial cells, the pretreatment of TMEE significantly downregulated the production of LPS-stimulated IL-1β, and TMEE was indicated to increase the expression of HO-1. In animal models exhibiting LPS-induced acute lung injury (ALI), treatment with TMEE reduced the levels of macrophages influx and TNF-α production in the bronchoalveolar lavage fluid (BALF) of ALI mice. Additionally, TMEE significantly downregulated the activation of ERK, JNK and IκB, and upregulated the expression of HO-1 in the lungs of ALI mice. In conclusion, the results of the current study demonstrated that TMEE could exert a regulatory role in the prevention or treatment of the endotoxin-mediated inflammatory response.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleThe anti-inflammatory effect of Trichilia martiana C. DC. in the lipopolysaccharide-stimulated inflammatory response in macrophages and airway epithelial cells and in LPS-challenged mice-
dc.title.alternativeThe anti-inflammatory effect of Trichilia martiana C. DC. in the lipopolysaccharide-stimulated inflammatory response in macrophages and airway epithelial cells and in LPS-challenged mice-
dc.typeArticle-
dc.citation.titleJournal of Microbiology and Biotechnology-
dc.citation.number11-
dc.citation.endPage1625-
dc.citation.startPage1614-
dc.citation.volume30-
dc.contributor.affiliatedAuthorJi Won Park-
dc.contributor.affiliatedAuthorHyung Won Ryu-
dc.contributor.affiliatedAuthorHye In Ahn-
dc.contributor.affiliatedAuthorJae-Hong Min-
dc.contributor.affiliatedAuthorSeong-Man Kim-
dc.contributor.affiliatedAuthorMin-Gu Kim-
dc.contributor.affiliatedAuthorOk-Kyoung Kwon-
dc.contributor.affiliatedAuthorDaseul Hwang-
dc.contributor.affiliatedAuthorSoo Yong Kim-
dc.contributor.affiliatedAuthorSangho Choi-
dc.contributor.affiliatedAuthorSei-Ryang Oh-
dc.contributor.affiliatedAuthorJae-Won Lee-
dc.contributor.affiliatedAuthorKyung Seop Ahn-
dc.contributor.alternativeName박지원-
dc.contributor.alternativeName류형원-
dc.contributor.alternativeName안혜인-
dc.contributor.alternativeName민재홍-
dc.contributor.alternativeName김성만-
dc.contributor.alternativeName김민구-
dc.contributor.alternativeName권옥경-
dc.contributor.alternativeName황다슬-
dc.contributor.alternativeName김수용-
dc.contributor.alternativeName최상호-
dc.contributor.alternativeNameZamora-
dc.contributor.alternativeNameRosales-
dc.contributor.alternativeName오세량-
dc.contributor.alternativeName이재원-
dc.contributor.alternativeName안경섭-
dc.identifier.bibliographicCitationJournal of Microbiology and Biotechnology, vol. 30, no. 11, pp. 1614-1625-
dc.identifier.doi10.4014/jmb.2006.06042-
dc.subject.keywordTrichilia martiana C. DC-
dc.subject.keywordmacrophage-
dc.subject.keywordinflammatory molecules-
dc.subject.keywordairway inflammation-
dc.subject.keywordNF-κB-
dc.subject.keywordacute lung injury-
dc.subject.localmacrophage-
dc.subject.localMacrophage-
dc.subject.localairway inflammation-
dc.subject.localAirway inflammation-
dc.subject.localNF-κB-
dc.subject.localNF-kB-
dc.subject.localacute lung injury-
dc.subject.localAcute lung injury-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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