두 종 입자를 이용한 다기능 생체물질 접합체의 제조방법 및 이로부터 제조된 다기능 생체물질 접합체

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Title
두 종 입자를 이용한 다기능 생체물질 접합체의 제조방법 및 이로부터 제조된 다기능 생체물질 접합체
Alternative Title
Method for Preparing Multi-functional Biomolecular Conjugates Using Two Kinds of Particle and Multi-functional Biomolecular Conjugates Prepared Therefrom
Inventor(s)
김민곤; 변주영; 성윤주
Assignee(s)
광주과학기술원,한국생명공학연구원
Application No.
14/351,291 (2014.04.11)
Registration No.
9,880,162 (2018.01.30)
Country
미국
Abstract
Disclosed herein are a method for manufacturing a multi-functional bio-material conjugate used as a biosensor for detecting microorganisms, and the like, and a multi-functional bio-material conjugate manufactured by means of the same. The method for manufacturing a multi-functional bio-material conjugate includes: (a) coating a first nanoparticle having magnetic or fluorescent characteristics with protein; (b) manufacturing a conjugate by adsorbing a second nanoparticle having metallic characteristics onto the first nanoparticle coated with protein; and (c) manufacturing the multi-functional bio-material conjugate by adsorbing a bio-material onto the conjugate. The method for manufacturing a multi-functional bio-material conjugate according to the present invention may prevent precipitation of the nanoparticles, easily immobilize the bio-material, and manufacture a bio-material conjugate having multiple functions, by using two kinds of the particles. In addition, the multi-functional bio-material conjugate manufactured by the present method may be used to detect microorganisms at up to a concentration of 101 cfu.
Type
Patent
Appears in Collections:
Division of Biomaterials Research > Bionanotechnology Research Center > 2. Patents
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