Anti-obesity activity of anthocyanin and carotenoid extracts from color-fleshed sweet potatoes

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Title
Anti-obesity activity of anthocyanin and carotenoid extracts from color-fleshed sweet potatoes
Author(s)
H J Kim; K A Koo; W S Park; D M Kang; Ho Soo Kim; B Y Lee; Y M Goo; J H Kim; M K Lee; D K Woo; Sang Soo Kwak; M J Ahn
Bibliographic Citation
Journal of Food Biochemistry, vol. 44, no. 10, pp. e13438-e13438
Publication Year
2020
Abstract
The anti-obesity effects of anthocyanin and carotenoid extracts from color-fleshed potatoes were studied with 3T3-L1 cells in vitro and high-fat diet (HFD)-induced obese mice in vivo. Treatment of 3T3-L1 adipocytes with anthocyanin and carotenoid extracts, respectively, after differentiation induction significantly inhibited fat accumulation by 63.1 and 83.5%. Studies of adipogenesis inhibition showed that the anthocyanin extract acts at intermediate stages, whereas the carotenoid extract influences all the stages. The extracts significantly diminished triglyceride (TG) content and peroxisome proliferator-activated receptor gamma (PPARγ) protein expression during adipogenesis of the intermediate stage. Oral administration of anthocyanin and carotenoid extracts, respectively, to HFD-fed mice significantly reduced weight gain and restored TG levels to normal or lower as compared to the HFD-fed group with improvement of a lipid profile, TG to HDL-C ratio. Histological differences in liver tissues revealed that the extracts protected the liver tissue from adipogenesis by HFD fed. This research presents the first direct demonstration that the two pigment extracts from sweet potato exhibit anti-obesity activities.
Keyword
anthocyanin and carotenoid extractsanti-obesityperoxisome proliferator-activated receptor gammasweet potatoestriglyceride
ISSN
0145-8884
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/jfbc.13438
Type
Article
Appears in Collections:
Division of Research on National Challenges > Plant Systems Engineering Research > 1. Journal Articles
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