Sargassum horneri as a functional food ameliorated IgE/BSA-induced mast cell activation and passive cutaneous anaphylaxis in mice

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dc.contributor.authorE J Han-
dc.contributor.authorH S Kim-
dc.contributor.authorK K A Sanjeewa-
dc.contributor.authorKyungsook Jung-
dc.contributor.authorY Jee-
dc.contributor.authorY J Jeon-
dc.contributor.authorI P S Fernando-
dc.contributor.authorG Ahn-
dc.date.accessioned2020-12-07T08:21:43Z-
dc.date.available2020-12-07T08:21:43Z-
dc.date.issued2020-
dc.identifier.issn16603397-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/23908-
dc.description.abstractSargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated activation in bone marrow-derived cultured-mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) reaction in mice. SHE markedly and dose-dependently suppressed the degranulation of BMCMCs by reducing the β-hexosaminidase and histamine release without cytotoxicity. In addition, SHE significantly decreased the FcεRI expression on the surface of BMCMCs and its IgE binding. Moreover, SHE reduced the mRNA expression and the production of allergic cytokines; interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-10, IL-13; interferon (IFN)-γ and/or tumor necrosis factor (TNF)-α; and a chemokine, thymus and activation-regulated chemokine (TARC), by suppressing the activation of Src-family kinases and nuclear factor (NF)-κB signaling. In further study, the application of SHE reduced the PCA reaction in an IgE/BSA-induced type I allergic mice model. Taken together, we suggest that SHE has an anti-allergic effect in type I allergic responses.-
dc.publisherMDPI-
dc.titleSargassum horneri as a functional food ameliorated IgE/BSA-induced mast cell activation and passive cutaneous anaphylaxis in mice-
dc.title.alternativeSargassum horneri as a functional food ameliorated IgE/BSA-induced mast cell activation and passive cutaneous anaphylaxis in mice-
dc.typeArticle-
dc.citation.titleMarine Drugs-
dc.citation.number12-
dc.citation.endPage594-
dc.citation.startPage594-
dc.citation.volume18-
dc.contributor.affiliatedAuthorKyungsook Jung-
dc.contributor.alternativeName한의정-
dc.contributor.alternativeName김현수-
dc.contributor.alternativeNameSanjeewa-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName지영흔-
dc.contributor.alternativeName전유진-
dc.contributor.alternativeNameFernando-
dc.contributor.alternativeName안긴애-
dc.identifier.bibliographicCitationMarine Drugs, vol. 18, no. 12, pp. 594-594-
dc.identifier.doi10.3390/md18120594-
dc.subject.keywordSargassum horneri-
dc.subject.keywordbone marrow-derived cultured-mast cells (BMCMCs)-
dc.subject.keywordimmunoglobuline-
dc.subject.keywordpassive cutaneous anaphylaxis (PCA)-
dc.subject.keywordanti-allergic effect-
dc.subject.localSargassum horneri-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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