DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jusik Min | - |
dc.contributor.author | D Halder | - |
dc.contributor.author | Ji Yong Yoon | - |
dc.contributor.author | Su Jin Jeon | - |
dc.contributor.author | Soo Young Jun | - |
dc.contributor.author | Jae-Ran Lee | - |
dc.contributor.author | Jeong Ju Lee | - |
dc.contributor.author | Min Hyuk Choi | - |
dc.contributor.author | Cho-Rok Jung | - |
dc.contributor.author | Da Yong Lee | - |
dc.contributor.author | B J Kim | - |
dc.contributor.author | Nam-Soon Kim | - |
dc.date.accessioned | 2020-12-08T11:51:00Z | - |
dc.date.available | 2020-12-08T11:51:00Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/23914 | - |
dc.description.abstract | The coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of CCDC50 in neuronal development are largely unknown. In this study, we showed that the depletion of CCDC50-V2 impeded the neuronal development process, including arbor formation, spine density development, and axonal outgrowth, in primary neurons. Mechanistic studies revealed that CCDC50-V2 positively regulated the nerve growth factor receptor, while it downregulated the epidermal growth factor receptor pathway. Importantly, JNK/c-Jun activation was found to be induced by the CCDC50-V2 overexpression, in which the interaction between CCDC50-V2 and JNK2 was also observed. Overall, the present study demonstrates a novel mechanism of CCDC50 function in neuronal development and provides new insight into the link between CCDC50 function and the aetiology of neurological disorders. | - |
dc.publisher | Springer-Nature Pub Group | - |
dc.title | Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth | - |
dc.title.alternative | Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth | - |
dc.type | Article | - |
dc.citation.title | Scientific Reports | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 21295 | - |
dc.citation.startPage | 21295 | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Jusik Min | - |
dc.contributor.affiliatedAuthor | Ji Yong Yoon | - |
dc.contributor.affiliatedAuthor | Su Jin Jeon | - |
dc.contributor.affiliatedAuthor | Soo Young Jun | - |
dc.contributor.affiliatedAuthor | Jae-Ran Lee | - |
dc.contributor.affiliatedAuthor | Jeong Ju Lee | - |
dc.contributor.affiliatedAuthor | Min Hyuk Choi | - |
dc.contributor.affiliatedAuthor | Cho-Rok Jung | - |
dc.contributor.affiliatedAuthor | Da Yong Lee | - |
dc.contributor.affiliatedAuthor | Nam-Soon Kim | - |
dc.contributor.alternativeName | 민주식 | - |
dc.contributor.alternativeName | Halder | - |
dc.contributor.alternativeName | 윤지용 | - |
dc.contributor.alternativeName | 전수진 | - |
dc.contributor.alternativeName | 전수영 | - |
dc.contributor.alternativeName | 이재란 | - |
dc.contributor.alternativeName | 이정주 | - |
dc.contributor.alternativeName | 최민혁 | - |
dc.contributor.alternativeName | 정초록 | - |
dc.contributor.alternativeName | 이다용 | - |
dc.contributor.alternativeName | 김병준 | - |
dc.contributor.alternativeName | 김남순 | - |
dc.identifier.bibliographicCitation | Scientific Reports, vol. 10, pp. 21295-21295 | - |
dc.identifier.doi | 10.1038/s41598-020-78304-3 | - |
dc.description.journalClass | Y | - |
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