Coiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth

Cited 2 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorJusik Min-
dc.contributor.authorD Halder-
dc.contributor.authorJi Yong Yoon-
dc.contributor.authorSu Jin Jeon-
dc.contributor.authorSoo Young Jun-
dc.contributor.authorJae-Ran Lee-
dc.contributor.authorJeong Ju Lee-
dc.contributor.authorMin Hyuk Choi-
dc.contributor.authorCho-Rok Jung-
dc.contributor.authorDa Yong Lee-
dc.contributor.authorB J Kim-
dc.contributor.authorNam-Soon Kim-
dc.date.accessioned2020-12-08T11:51:00Z-
dc.date.available2020-12-08T11:51:00Z-
dc.date.issued2020-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/23914-
dc.description.abstractThe coiled-coil domain containing 50 (CCDC50) protein is a phosphotyrosine-dependent signalling protein stimulated by epidermal growth factor. It is highly expressed in neuronal cells in the central nervous system; however, the roles of CCDC50 in neuronal development are largely unknown. In this study, we showed that the depletion of CCDC50-V2 impeded the neuronal development process, including arbor formation, spine density development, and axonal outgrowth, in primary neurons. Mechanistic studies revealed that CCDC50-V2 positively regulated the nerve growth factor receptor, while it downregulated the epidermal growth factor receptor pathway. Importantly, JNK/c-Jun activation was found to be induced by the CCDC50-V2 overexpression, in which the interaction between CCDC50-V2 and JNK2 was also observed. Overall, the present study demonstrates a novel mechanism of CCDC50 function in neuronal development and provides new insight into the link between CCDC50 function and the aetiology of neurological disorders.-
dc.publisherSpringer-Nature Pub Group-
dc.titleCoiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth-
dc.title.alternativeCoiled-coil domain containing 50-V2 protein positively regulates neurite outgrowth-
dc.typeArticle-
dc.citation.titleScientific Reports-
dc.citation.number0-
dc.citation.endPage21295-
dc.citation.startPage21295-
dc.citation.volume10-
dc.contributor.affiliatedAuthorJusik Min-
dc.contributor.affiliatedAuthorJi Yong Yoon-
dc.contributor.affiliatedAuthorSu Jin Jeon-
dc.contributor.affiliatedAuthorSoo Young Jun-
dc.contributor.affiliatedAuthorJae-Ran Lee-
dc.contributor.affiliatedAuthorJeong Ju Lee-
dc.contributor.affiliatedAuthorMin Hyuk Choi-
dc.contributor.affiliatedAuthorCho-Rok Jung-
dc.contributor.affiliatedAuthorDa Yong Lee-
dc.contributor.affiliatedAuthorNam-Soon Kim-
dc.contributor.alternativeName민주식-
dc.contributor.alternativeNameHalder-
dc.contributor.alternativeName윤지용-
dc.contributor.alternativeName전수진-
dc.contributor.alternativeName전수영-
dc.contributor.alternativeName이재란-
dc.contributor.alternativeName이정주-
dc.contributor.alternativeName최민혁-
dc.contributor.alternativeName정초록-
dc.contributor.alternativeName이다용-
dc.contributor.alternativeName김병준-
dc.contributor.alternativeName김남순-
dc.identifier.bibliographicCitationScientific Reports, vol. 10, pp. 21295-21295-
dc.identifier.doi10.1038/s41598-020-78304-3-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.