Anti-Inflammatory activities of an extract of in vitro grown adventitious shoots of Toona sinensis in LPS-treated RAW264.7 and Propionibacterium acnes-treated HaCaT cells

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Title
Anti-Inflammatory activities of an extract of in vitro grown adventitious shoots of Toona sinensis in LPS-treated RAW264.7 and Propionibacterium acnes-treated HaCaT cells
Author(s)
H J Lim; I S Park; Eun Yee Jie; Woo-Seok Ahn; S J Kim; S I Jeong; K Y Yu; Suk Weon Kim; C H Jung
Bibliographic Citation
Plants-Basel, vol. 9, no. 12, pp. 1701-1701
Publication Year
2020
Abstract
Toona sinensis has been traditionally used to treat dysentery, enteritis, flatulence, and itchiness. However, the existence of anti-inflammatory effects of T. sinensis on Propionibacterium acnes-induced skin disease is unknown. In vitro cultures of plant cells and tissues produced under controlled conditions offer a continuous production platform for plant natural products including pigments and anti-inflammatory agents. In this study, we determine the anti-inflammatory activities of an extract of in vitro grown adventitious shoots of T. sinensis on P. acnes, the etiologic agent of skin inflammation. The extract of T. sinensis showed antioxidant and anti-inflammatory activity in LPS-treated RAW264.7 cells. It also had antibacterial activity and anti-inflammatory effects on P. acnes-treated HaCaT cells. In addition, these effects were regulated by suppression of the mitogen-activated protein kinase (MAPK) pathways. These results suggesting the potential application of adventitious shoots of T. sinensis grown with an in vitro proliferation system as a medicine for treating P. acnes-induced inflammatory skin disease.
Keyword
Toona sinensisadventitious shootsantioxidationantibacterial activityanti-inflammationP. acnes-induced inflammatory disease
ISSN
2223-7747
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/plants9121701
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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