Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis

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Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis
Hyung Jin Lim; S I Park; Seon Gyeong Bak; S H Cheong; Soyoung Lee; Y B Baek; C M Lee; K M Lee; Seung Woong LeeSeung Jae LeeMun Chual Rho
Bibliographic Citation
Food Science & Nutrition, vol. 8, no. 12, pp. 6550-6556
Publication Year
In Asia, Vigna angularis (azuki bean) has been used as a traditional medicine to treat various diseases because of its biological properties. Osteoarthritis (OA) and osteoporosis (OP) are common regenerative bone diseases that are characterized by deterioration of joint and bone structure. In this study, we evaluated the effects of Vigna angularis extract (VAE) on monosodium iodoacetate (MIA)-induced OA and ovariectomy (OVX)-induced OP models. In the MIA-induced OA results, severe OA was alleviated by the administration of VAE. Extensive local damage in the cartilage and hemorrhagic and edematous of surrounding tissues were decreased by VAE treatment. Articular cartilage was almost intact except for a focal mild abrasion, and the surface was glistening, similar to that of the normal joint. In the OVX-induced OP results, bone mineral content (BMC) and bone mineral density (BMD) were recovered by VAE treatment, and it improved the microstructures of bone. These results show that VAE could inhibit OA and OP symptoms.
Monosodium iodoacetateOsteoarthritisOsteoporosisOvariectomyVigna angularis
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Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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