Evaluation of 13-week subchronic toxicity of Platycodon grandiflorus (Jacq.) A.DC. root extract in rats

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dc.contributor.authorS B Cha-
dc.contributor.authorY Li-
dc.contributor.authorJ S Bae-
dc.contributor.authorS W Song-
dc.contributor.authorIn Chul Lee-
dc.contributor.authorJ C Kim-
dc.date.accessioned2020-12-23T01:53:29Z-
dc.date.available2020-12-23T01:53:29Z-
dc.date.issued2021-
dc.identifier.issn0378-8741-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/23942-
dc.description.abstractEthnopharmacological relevance: Platycodi radix is widely used in traditional herbal medicine for bronchitis, asthma, pulmonary tuberculosis, hypertension, hyperlipidemia, and diabetes. However, data on safety of Platycodi radix are insufficient. Aim of the study: The present study was performed to evaluate the potential subchronic toxicity of Platycodi radix water extract through a 13-week repeated oral dose experiment in Sprague-Dawley rats. Materials and methods: Forty male and 40 female rats were randomly assigned to four experimental groups: three treatment groups receiving 300, 1000, and 3000 mg/kg/day of Platycodi radix water extract and a vehicle control group receiving sterile distilled water for 13 weeks. Results: Repeated oral administration of the Platycodi radix water extract to rats resulted in an increased incidence of centrilobular hepatocellular hypertrophy in the liver, diffuse follicular cell hypertrophy in the thyroid gland, and squamous hyperplasia of the limiting ridge in the stomach at dose levels of ≥500 mg/kg/day of both genders. However, these findings are considered be adaptive non-adverse changes because these findings were observed without organ weight change or clinical pathology alterations. No treatment-related effects on clinical signs, body weight, food and water consumption, ophthalmic examination, urinalysis, hematology, serum biochemistry, necropsy findings, and organ weights were observed at any dose tested. Conclusion: Under the present experimental conditions, the no-observed-adverse-effect level of the Platycodi radix water extract was considered to be ≥ 3000 mg/kg/day in rats, and no target organs were identified.-
dc.publisherElsevier-
dc.titleEvaluation of 13-week subchronic toxicity of Platycodon grandiflorus (Jacq.) A.DC. root extract in rats-
dc.title.alternativeEvaluation of 13-week subchronic toxicity of Platycodon grandiflorus (Jacq.) A.DC. root extract in rats-
dc.typeArticle-
dc.citation.titleJournal of Ethnopharmacology-
dc.citation.number0-
dc.citation.endPage113621-
dc.citation.startPage113621-
dc.citation.volume267-
dc.contributor.affiliatedAuthorIn Chul Lee-
dc.contributor.alternativeName차승범-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName배진숙-
dc.contributor.alternativeName송시환-
dc.contributor.alternativeName이인철-
dc.contributor.alternativeName김종춘-
dc.identifier.bibliographicCitationJournal of Ethnopharmacology, vol. 267, pp. 113621-113621-
dc.identifier.doi10.1016/j.jep.2020.113621-
dc.subject.keywordHerbal medicine-
dc.subject.keywordPlatycodi radix-
dc.subject.keywordRepeated dose toxicity-
dc.subject.keywordNo-observed-adverse-effect level-
dc.subject.keywordTarget organ-
dc.subject.localHerbal medicine-
dc.subject.localherbal medicine-
dc.subject.localPlatycodi radix-
dc.subject.localPlatycodi Radix-
dc.subject.localplatycodi radix-
dc.subject.localrepeated dose toxicity-
dc.subject.localRepeated dose toxicity-
dc.subject.localNo-observed-adverse-effect level-
dc.subject.localTarget organ-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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