SETDB1 overexpression sets an intertumoral transcriptomic divergence in non-small cell lung carcinoma

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dc.contributor.authorYong-Kook Kang-
dc.contributor.authorByungkuk Min-
dc.date.accessioned2020-12-23T01:53:34Z-
dc.date.available2020-12-23T01:53:34Z-
dc.date.issued2020-
dc.identifier.issn16648021-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/23944-
dc.description.abstractAn increasing volume of evidence suggests that SETDB1 plays a role in the tumorigenesis of various cancers, classifying SETDB1 as an oncoprotein. However, owing to its numerous protein partners and their global-scale effects, the molecular mechanism underlying SETDB1-involved oncogenesis remains ambiguous. In this study, using public transcriptome data of lung adenocarcinoma (ADC) and squamous-cell carcinoma (SCC), we compared tumors with high-level SETDB1 (SH) and those with low-level SETDB1 (comparable with normal samples; SL). The results of principal component analysis revealed a transcriptomic distinction and divergence between the SH and SL samples in both ADCs and SCCs. The results of gene set enrichment analysis indicated that genes involved in the "epithelial-mesenchymal transition," "innate immune response," and "autoimmunity" collections were significantly depleted in SH tumors, whereas those involved in "RNA interference" collections were enriched. Chromatin-modifying genes were highly expressed in SH tumors, and the variance in their expression was incomparably high in SCC-SH, which suggested greater heterogeneity within SCC tumors. DNA methyltransferase genes were also overrepresented in SH samples, and most differentially methylated CpGs (SH/SL) were undermethylated in a highly biased manner in ADCs. We identified interesting molecular signatures associated with the possible roles of SETDB1 in lung cancer. We expect these SETDB1-associated molecular signatures to facilitate the development of biologically relevant targeted therapies for particular types of lung cancer.-
dc.publisherFrontiers Media Sa-
dc.titleSETDB1 overexpression sets an intertumoral transcriptomic divergence in non-small cell lung carcinoma-
dc.title.alternativeSETDB1 overexpression sets an intertumoral transcriptomic divergence in non-small cell lung carcinoma-
dc.typeArticle-
dc.citation.titleFrontiers in Genetics-
dc.citation.number0-
dc.citation.endPage573515-
dc.citation.startPage573515-
dc.citation.volume11-
dc.contributor.affiliatedAuthorYong-Kook Kang-
dc.contributor.affiliatedAuthorByungkuk Min-
dc.contributor.alternativeName강용국-
dc.contributor.alternativeName민병국-
dc.identifier.bibliographicCitationFrontiers in Genetics, vol. 11, pp. 573515-573515-
dc.identifier.doi10.3389/fgene.2020.573515-
dc.subject.keywordLung cancer-
dc.subject.keywordSETDB1-
dc.subject.keywordIntertumor heterogeneity-
dc.subject.keywordEpithelial-mesenchymal transition-
dc.subject.keywordRNA interference-
dc.subject.localLung cancer-
dc.subject.localSETDB1-
dc.subject.localEpithelial-mesenchymal transition-
dc.subject.localEpithelial-mesenchymal transition (EMT)-
dc.subject.localRNA interference-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
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