Potential roles of exercise-induced plasma metabolites linking exercise to health benefits

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Title
Potential roles of exercise-induced plasma metabolites linking exercise to health benefits
Author(s)
Yong Ryoul YangKi-Sun Kwon
Bibliographic Citation
Frontiers in Physiology, vol. 11, pp. 602748-602748
Publication Year
2020
Abstract
Regular exercise has a myriad of health benefits. An increase in circulating exercise factors following exercise is a critical physiological response. Numerous studies have shown that exercise factors released from tissues during physical activity may contribute to health benefits via autocrine, paracrine, and endocrine mechanisms. Myokines, classified as proteins secreted from skeletal muscle, are representative exercise factors. The roles of myokines have been demonstrated in a variety of exercise-related functions linked to health benefits. In addition to myokines, metabolites are also exercise factors. Exercise changes the levels of various metabolites via metabolic reactions. Several studies have identified exercise-induced metabolites that positively influence organ functions. Here, we provide an overview of selected metabolites secreted into the circulation upon exercise.
Keyword
ExerciseMetabolitesalpha-ketoglutarate (α-KG)beta-aminoisobutyric acid (BAIBA)Kynurenic acid (KYNA)β-hydroxybutyrate (BHB)Lactate12,13-diHOME
ISSN
1664-042X
Publisher
Frontiers Media Sa
DOI
http://dx.doi.org/10.3389/fphys.2020.602748
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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