Anti-proliferative effect of Allium senescens L. extract in human T-cell acute lymphocytic leukemia cells

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Title
Anti-proliferative effect of Allium senescens L. extract in human T-cell acute lymphocytic leukemia cells
Author(s)
J Kim; D H Lee; B Badamtsetseg; Sangwoo Lee; S A Kim
Bibliographic Citation
Molecules, vol. 26, no. 1, pp. 35-35
Publication Year
2021
Abstract
Allium species are well known plants distributed throughout the world, and they contain various bioactive components with different biological activities including anti-cancer effects. In this study, we investigated the inhibitory effect of Allium senescens L. (A.S.) extract on cell survival and IL-2-mediated inflammation in human T cell acute lymphocytic leukemia (T-ALL) Jurkat cells. Our results showed that A.S. extract induced caspase-dependent apoptosis of Jurkat cells with no significant cytotoxicity in the normal peripheral blood mononuclear cells. A.S. extract induced ROS generation through the activation of MAPK p38 phosphorylation. It also inhibited IL-2 mRNA expression and NF-κB signaling mediated by phorbol 12-myristate 13-acetate, and phytohemagglutinin. Combined treatment with A.S. extract and axitinib/dovitinib exerted enhanced inhibitory effects on T-ALL cell growth and IL-2 production. These results provide novel information on the potential use of A.S. extract as a therapeutic herbal agent for the treatment and prevention of T-ALL.
Keyword
Allium senescens L.ApoptosisAxitinibDovitinibLeukemiaT-ALL
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules26010035
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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