3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome

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dc.contributor.authorK Kim-
dc.contributor.authorInsu Jang-
dc.contributor.authorM Kim-
dc.contributor.authorJinhyuk Choi-
dc.contributor.authorM S Kim-
dc.contributor.authorByungwook Lee-
dc.contributor.authorI Jung-
dc.date.accessioned2021-01-07T03:31:32Z-
dc.date.available2021-01-07T03:31:32Z-
dc.date.issued2021-
dc.identifier.issn03051048-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/23975-
dc.description.abstractThree-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, various types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic gene expression. However, unraveling the pathogenicity of the 3D cancer genome remains a challenge since closer examinations have been greatly limited due to the lack of appropriate tools specialized for disorganized higher-order chromatin structure. Here, we updated a 3D-genome Interaction Viewer and database named 3DIV by uniformly processing ∼230 billion raw Hi-C reads to expand our contents to the 3D cancer genome. The updates of 3DIV are listed as follows: (i) the collection of 401 samples including 220 cancer cell line/tumor Hi-C data, 153 normal cell line/tissue Hi-C data, and 28 promoter capture Hi-C data, (ii) the live interactive manipulation of the 3D cancer genome to simulate the impact of structural variations and (iii) the reconstruction of Hi-C contact maps by user-defined chromosome order to investigate the 3D genome of the complex genomic rearrangement. In summary, the updated 3DIV will be the most comprehensive resource to explore the gene regulatory effects of both the normal and cancer 3D genome. '3DIV' is freely available at http://3div.kr.-
dc.publisherOxford Univ Press-
dc.title3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome-
dc.title.alternative3DIV update for 2021: a comprehensive resource of 3D genome and 3D cancer genome-
dc.typeArticle-
dc.citation.titleNucleic Acids Research-
dc.citation.numberD-
dc.citation.endPageD46-
dc.citation.startPageD38-
dc.citation.volume49-
dc.contributor.affiliatedAuthorInsu Jang-
dc.contributor.affiliatedAuthorJinhyuk Choi-
dc.contributor.affiliatedAuthorM S Kim-
dc.contributor.affiliatedAuthorByungwook Lee-
dc.contributor.alternativeName김규광-
dc.contributor.alternativeName장인수-
dc.contributor.alternativeName김무영-
dc.contributor.alternativeName최진혁-
dc.contributor.alternativeName김민서-
dc.contributor.alternativeName이병욱-
dc.contributor.alternativeName정인경-
dc.identifier.bibliographicCitationNucleic Acids Research, vol. 49, no. D, pp. D38-D46-
dc.identifier.doi10.1093/nar/gkaa1078-
dc.description.journalClassY-
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Korea Bioinformation Center > 1. Journal Articles
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