The patterns of deleterious mutations during the domestication of soybean

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Title
The patterns of deleterious mutations during the domestication of soybean
Author(s)
Myung-Shin Kim; R Lozano; Ji Hong Kim; Dong Nyuk Bae; S T Kim; Jung-Ho Park; M S Choi; J Kim; H C Ok; S K Park; M A Gore; J K Moon; Soon-Chun Jeong
Bibliographic Citation
Nature Communications, vol. 12, pp. 97-97
Publication Year
2021
Abstract
Globally, soybean is a major protein and oil crop. Enhancing our understanding of the soybean domestication and improvement process helps boost genomics-assisted breeding efforts. Here we present a genome-wide variation map of 10.6 million single-nucleotide polymorphisms and 1.4 million indels for 781 soybean individuals which includes 418 domesticated (Glycine max), 345 wild (Glycine soja), and 18 natural hybrid (G. max/G. soja) accessions. We describe the enhanced detection of 183 domestication-selective sweeps and the patterns of putative deleterious mutations during domestication and improvement. This predominantly selfing species shows 7.1% reduction of overall deleterious mutations in domesticated soybean relative to wild soybean and a further 1.4% reduction from landrace to improved accessions. The detected domestication-selective sweeps also show reduced levels of deleterious alleles. Importantly, genotype imputation with this resource increases the mapping resolution of genome-wide association studies for seed protein and oil traits in a soybean diversity panel.
ISSN
2041-1723
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/s41467-020-20337-3
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Bio-Evaluation Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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