The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis

Cited 11 time in scopus
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The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis
Kyunghee Noh; D H Bach; H J Choi; M S Kim; S Y Wu; S Pradeep; C lvan; M S Cho; E Bayraktar; C Rodriguez-Aguayo; S K Dasari; E Stur; L S Mangala; G Lopez-Berestein; A K Sood
Bibliographic Citation
Oncogene, vol. 40, no. 2, pp. 384-395
Publication Year
Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer patient data, cell lines, and orthotopic mouse models. We demonstrated a previously unrecognized mechanism whereby nuclear PXN enhances angiogenesis by transcriptionally regulating SRC expression. SRC, in turn, increases PLAT expression through NF-ĸB activation; PLAT promotes angiogenesis via LRP1 in endothelial cells. PXN silencing in ovarian cancer mouse models reduced angiogenesis, tumor growth, and metastasis. These findings provide a new understanding of the role of PXN in regulating tumor angiogenesis and growth.
Springer-Nature Pub Group
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Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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