Bombyx batryticatus protein-rich extract induces maturation of dendritic cells and Th1 polarization: a potential immunological adjuvant for cancer vaccine

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dc.contributor.authorH Y Song-
dc.contributor.authorJ M Han-
dc.contributor.authorE H Byun-
dc.contributor.authorWoo Sik Kim-
dc.contributor.authorH S Seo-
dc.contributor.authorE B Byun-
dc.date.accessioned2021-01-26T03:34:27Z-
dc.date.available2021-01-26T03:34:27Z-
dc.date.issued2021-
dc.identifier.issn1420-3049-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24030-
dc.description.abstractBombyx batryticatus, a protein-rich edible insect, is widely used as a traditional medicine in China. Several pharmacological studies have reported the anticancer activity of B. batryticatus extracts; however, the capacity of B. batryticatus extracts as immune potentiators for increasing the efficacy of cancer immunotherapy is still unverified. In the present study, we investigated the immunomodulatory role of B. batryticatus protein-rich extract (BBPE) in bone marrow-derived dendritic cells (BMDCs) and DC vaccine-immunized mice. BBPE-treated BMDCs displayed characteristics of mature immune status, including high expression of surface molecules (CD80, CD86, major histocompatibility complex (MHC)-I, and MHC-II), increased production of proinflammatory cytokines (tumor necrosis factor-α and interleukin-12p70), enhanced antigen-presenting ability, and reduced endocytosis. BBPE-treated BMDCs promoted naive CD4+ and CD8+ T-cell proliferation and activation. Furthermore, BBPE/ovalbumin (OVA)-pulsed DC-immunized mice showed a stronger OVA-specific multifunctional T-cell response in CD4+ and CD8+ T cells and a stronger Th1 antibody response than mice receiving differently treated DCs, which showed the enhanced protective effect against tumor growth in E.G7 tumor-bearing mice. Our data demonstrate that BBPE can be a novel immune potentiator for a DC-based vaccine in anticancer therapy.-
dc.publisherMDPI-
dc.titleBombyx batryticatus protein-rich extract induces maturation of dendritic cells and Th1 polarization: a potential immunological adjuvant for cancer vaccine-
dc.title.alternativeBombyx batryticatus protein-rich extract induces maturation of dendritic cells and Th1 polarization: a potential immunological adjuvant for cancer vaccine-
dc.typeArticle-
dc.citation.titleMolecules-
dc.citation.number2-
dc.citation.endPage476-
dc.citation.startPage476-
dc.citation.volume26-
dc.contributor.affiliatedAuthorWoo Sik Kim-
dc.contributor.alternativeName송하연-
dc.contributor.alternativeName한정무-
dc.contributor.alternativeName변의홍-
dc.contributor.alternativeName김우식-
dc.contributor.alternativeName서호성-
dc.contributor.alternativeName변의백-
dc.identifier.bibliographicCitationMolecules, vol. 26, no. 2, pp. 476-476-
dc.identifier.doi10.3390/molecules26020476-
dc.subject.keywordBombyx batryticatus extract-
dc.subject.keywordDendritic cells-
dc.subject.keywordCancer vaccine-
dc.subject.keywordMultifunctional T cells-
dc.subject.keywordAminoacid composition-
dc.subject.keywordImmunopotentiator-
dc.subject.localBombyx batryticatus extract-
dc.subject.localDendritic cell-
dc.subject.localDendritic cells (DC)-
dc.subject.localdendritic cells-
dc.subject.localDendritic cells (DCs)-
dc.subject.localDendritic cells-
dc.subject.localdendritic cells (DC)-
dc.subject.localdendritic cell-
dc.subject.localCancer vaccines-
dc.subject.localCancer vaccine-
dc.subject.localMultifunctional T cells-
dc.subject.localAminoacid composition-
dc.subject.localImmunopotentiator-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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