Risk assessment and evaluation of epidermal growth factor (EGF) transgenic soybean: responses of Cyprinus carpio fed on EGF transgenic soybean

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dc.contributor.authorS D Oh-
dc.contributor.authorS K Min-
dc.contributor.authorJ K Kim-
dc.contributor.authorJung-Ho Park-
dc.contributor.authorChang-Gi Kim-
dc.contributor.authorS Y Park-
dc.date.accessioned2021-01-30T03:30:27Z-
dc.date.available2021-01-30T03:30:27Z-
dc.date.issued2020-
dc.identifier.issn2466-2402-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24052-
dc.description.abstractThe epidermal growth factor (EGF) transgenic soybean was developed and biosynthesis of human epidermal growth factor (hEGF) in soybean seeds was confirmed. Also, EGF transgenic soybean were found to contain a herbicide resistance selectable marker by introduction of phosphinothricin acetyltransferase (PAT ) gene from the Streptomyces hygroscopicus. For biosafety assessment, the EGF transgenic soybean expressing the EGF biosynthesis gene EGF and herbicide resistant gene PAT was tested to determine effects on survival of Cyprinus carpio, commonly used as a model organism in ecotoxicological studies. C. carpio was fed 100% ground soybean suspension, EGF soybean or non-genetically modified (GM) counterpart soybean (Gwangan). Gene expression of EGF soybean was confirmed by PCR and ELISA to have EGF/PAT. Feeding test showed that no significant differences in cumulative immobility or abnormal response between C. carpio samples fed on EGF soybean and non-GM counterpart soybean. The 48 h-EC50 values of the EGF and non-GM soybean were 1,688 mg·L-1 (95% confidence limits: 1,585 - 1,798 mg·L-1) and 1,575 mg·L-1 (95% confidence limits: 1,433 - 1,731 mg·L-1), respectively. The soybean NOEC (no observed effect concentration) value for C. carpio was suggested to be 625 mg·L-1. We concluded that there was no significant difference in toxicity for non-target organisms (C. carpio) between the EGF soybean and non-GM counterparts.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleRisk assessment and evaluation of epidermal growth factor (EGF) transgenic soybean: responses of Cyprinus carpio fed on EGF transgenic soybean-
dc.title.alternativeRisk assessment and evaluation of epidermal growth factor (EGF) transgenic soybean: responses of Cyprinus carpio fed on EGF transgenic soybean-
dc.typeArticle-
dc.citation.titleKorean Journal of Agricultural Science-
dc.citation.number4-
dc.citation.endPage827-
dc.citation.startPage815-
dc.citation.volume47-
dc.contributor.affiliatedAuthorJung-Ho Park-
dc.contributor.affiliatedAuthorChang-Gi Kim-
dc.contributor.alternativeName오성덕-
dc.contributor.alternativeName민석기-
dc.contributor.alternativeName김재광-
dc.contributor.alternativeName박정호-
dc.contributor.alternativeName김창기-
dc.contributor.alternativeName박수연-
dc.identifier.bibliographicCitationKorean Journal of Agricultural Science, vol. 47, no. 4, pp. 815-827-
dc.identifier.doi10.7744/kjoas.20200068-
dc.subject.keywordCyprinus carpio-
dc.subject.keywordGenetically modified (GM) soybean-
dc.subject.keywordRisk assessment-
dc.subject.localCyprinus carpio-
dc.subject.localGenetically modified (GM) soybean-
dc.subject.localrisk assessment-
dc.subject.localRisk Assessment-
dc.subject.localRisk assessment-
dc.description.journalClassN-
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Division of Bio Technology Innovation > Bio-Evaluation Center > 1. Journal Articles
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