Sjogren syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human

Cited 3 time in scopus
Metadata Downloads
Title
Sjogren syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human
Author(s)
Seong Heon Kim; Bi-Oh Park; Kidae Kim; Byoung Chul ParkSung Goo ParkJeong Hoon Kim; S Kim
Bibliographic Citation
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1864, pp. 194684-194684
Publication Year
2021
Abstract
LIN28 protein and let-7 family micro RNAs (miRNAs) that are an evolutionarily conserved from nematodes to humans are the important regulators of developmental timing by dynamically interacting with each other. However, regulators of LIN28 remain largely elusive. Here, we show the evidences that Sjogren Syndrome antigen B (SSB) protein associates and cooperates with LIN28A and LIN28B, mammalian orthologues of Caenorhabditis elegans lin-28, proteins in the nucleus. Knockdown of SSB in HEK293 cell line resulted in the decrease of the amount of LIN28B mRNAs and proteins, and the increase of the level of mature let-7 miRNAs. Furthermore, RNA interference of ssb-1 gene, a worm SSB orthologue, was sufficient to cause a heterochronic defect in seam cells of C. elegans, recapitulating the phenotype of lin-28 downregulation. Collectively, we suggest that SSB is an important regulator for the LIN28-let-7 axis.
Keyword
LIN28Let-7SSBmiRNAProtein-protein interactionHeterochronic signaling
ISSN
1874-9399
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbagrm.2021.194684
Type
Article
Appears in Collections:
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.