Sjogren syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human

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Sjogren syndrome antigen B regulates LIN28-let-7 axis in Caenorhabditis elegans and human
Seong Heon Kim; Bi-Oh Park; Kidae Kim; Byoung Chul ParkSung Goo ParkJeong Hoon Kim; S Kim
Bibliographic Citation
Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, vol. 1864, pp. 194684-194684
Publication Year
LIN28 protein and let-7 family micro RNAs (miRNAs) that are an evolutionarily conserved from nematodes to humans are the important regulators of developmental timing by dynamically interacting with each other. However, regulators of LIN28 remain largely elusive. Here, we show the evidences that Sjogren Syndrome antigen B (SSB) protein associates and cooperates with LIN28A and LIN28B, mammalian orthologues of Caenorhabditis elegans lin-28, proteins in the nucleus. Knockdown of SSB in HEK293 cell line resulted in the decrease of the amount of LIN28B mRNAs and proteins, and the increase of the level of mature let-7 miRNAs. Furthermore, RNA interference of ssb-1 gene, a worm SSB orthologue, was sufficient to cause a heterochronic defect in seam cells of C. elegans, recapitulating the phenotype of lin-28 downregulation. Collectively, we suggest that SSB is an important regulator for the LIN28-let-7 axis.
LIN28Let-7SSBmiRNAProtein-protein interactionHeterochronic signaling
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Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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