The nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation

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dc.contributor.authorP Dhillon-
dc.contributor.authorJ Park-
dc.contributor.authorC H Pozo-
dc.contributor.authorL Li-
dc.contributor.authorT Doke-
dc.contributor.authorS Huang-
dc.contributor.authorJ Zhao-
dc.contributor.authorHyun Mi Kang-
dc.contributor.authorR Shrestra-
dc.contributor.authorM S Balzer-
dc.contributor.authorS Chatterjee-
dc.contributor.authorP Prado-
dc.contributor.authorS Y Han-
dc.contributor.authorH Liu-
dc.contributor.authorX Sheng-
dc.contributor.authorP Dierickx-
dc.contributor.authorK Batmanov-
dc.contributor.authorJ P Romero-
dc.contributor.authorF Prosper-
dc.contributor.authorM Li-
dc.contributor.authorL Pei-
dc.contributor.authorJ Kim-
dc.contributor.authorN Montserrat-
dc.contributor.authorK Susztak-
dc.date.accessioned2021-02-05T03:30:27Z-
dc.date.available2021-02-05T03:30:27Z-
dc.date.issued2021-
dc.identifier.issn1550-4131-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24061-
dc.description.abstractKidney disease is poorly understood because of the organ's cellular diversity. We used single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular composition but also in cell-type-specific gene expression in mouse models of kidney disease. This analysis highlighted major changes in cellular diversity in kidney disease, which markedly impacted whole-kidney transcriptomics outputs. Cell-type-specific differential expression analysis identified proximal tubule (PT) cells as the key vulnerable cell type. Through unbiased cell trajectory analyses, we show that PT cell differentiation is altered in kidney disease. Metabolism (fatty acid oxidation and oxidative phosphorylation) in PT cells showed the strongest and most reproducible association with PT cell differentiation and disease. Coupling of cell differentiation and the metabolism was established by nuclear receptors (estrogen-related receptor alpha [ESRRA] and peroxisomal proliferation-activated receptor alpha [PPARA]) that directly control metabolic and PT-cell-specific gene expression in mice and patient samples while protecting from kidney disease in the mouse model.-
dc.publisherElsevier-Cell Press-
dc.titleThe nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation-
dc.title.alternativeThe nuclear receptor ESRRA protects from kidney disease by coupling metabolism and differentiation-
dc.typeArticle-
dc.citation.titleCell Metabolism-
dc.citation.number2-
dc.citation.endPage394-
dc.citation.startPage379-
dc.citation.volume33-
dc.contributor.affiliatedAuthorHyun Mi Kang-
dc.contributor.alternativeNameDhillon-
dc.contributor.alternativeName박지환-
dc.contributor.alternativeNamePozo-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeNameDoke-
dc.contributor.alternativeNameHuang-
dc.contributor.alternativeNameZhao-
dc.contributor.alternativeName강현미-
dc.contributor.alternativeNameShrestra-
dc.contributor.alternativeNameBalzer-
dc.contributor.alternativeNameChatterjee-
dc.contributor.alternativeNamePrado-
dc.contributor.alternativeName한승엽-
dc.contributor.alternativeNameLiu-
dc.contributor.alternativeNameSheng-
dc.contributor.alternativeNameDierickx-
dc.contributor.alternativeNameBatmanov-
dc.contributor.alternativeNameRomero-
dc.contributor.alternativeNameProsper-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeNamePei-
dc.contributor.alternativeName김준형-
dc.contributor.alternativeNameMontserrat-
dc.contributor.alternativeNameSusztak-
dc.identifier.bibliographicCitationCell Metabolism, vol. 33, no. 2, pp. 379-394-
dc.identifier.doi10.1016/j.cmet.2020.11.011-
dc.subject.keywordsingle-cell RNA sequencing-
dc.subject.keywordsingle-cell ATAC sequencing-
dc.subject.keywordkidney-
dc.subject.keywordfibrosis-
dc.subject.keywordorganoids-
dc.subject.keywordfatty-acid oxidation-
dc.subject.keywordPPARA-
dc.subject.keywordESRRA-
dc.subject.keywordproximal tubule cells-
dc.subject.keywordchronic kidney disease-
dc.subject.localsingle-cell RNA sequencing-
dc.subject.localSinglecell RNA sequencing-
dc.subject.localsingle-cell ATAC sequencing-
dc.subject.localkidney-
dc.subject.localKidney-
dc.subject.localFibrosis-
dc.subject.localfibrosis-
dc.subject.localOrganoids-
dc.subject.localorganoid-
dc.subject.localorganoids-
dc.subject.localOrganoid-
dc.subject.localfatty-acid oxidation-
dc.subject.localPPARA-
dc.subject.localESRRA-
dc.subject.localproximal tubule cells-
dc.subject.localProximal tubule cells-
dc.subject.localchronic kidney disease-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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