MicroRNA-based therapeutics for drug-rsistant colorectal cancer

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Title
MicroRNA-based therapeutics for drug-rsistant colorectal cancer
Author(s)
Eunsun Jung; Jinhyeon Choi; Jang Seong Kim; Tae-Su Han
Bibliographic Citation
Pharmaceuticals, vol. 14, no. 2, pp. 136-136
Publication Year
2021
Abstract
Although therapeutic approaches for patients with colorectal cancer (CRC) have improved in the past decades, the problem of drug resistance still persists and acts as a major obstacle for effective therapy. Many studies have shown that drug resistance is related to reduced drug uptake, modification of drug targets, and/or transformation of cell cycle checkpoints. A growing body of evidence indicates that several microRNAs (miRNAs) may contribute to the drug resistance to chemotherapy, targeted therapy, and immunotherapy by regulating the drug resistance-related target genes in CRC. These drug resistance-related miRNAs may be used as promising biomarkers for predicting drug response or as potential therapeutic targets for treating patients with CRC. In this review, we summarized the recent discoveries regarding anti-cancer drug-related miRNAs and their molecular mechanisms in CRC. Furthermore, we discussed the challenges associated with the clinical application of miRNAs as biomarkers for the diagnosis of drug-resistant patients and as therapeutic targets for CRC treatment.
Keyword
MicroRNAChemoresistanceTargeted therapyImmunotherapyAnti-cancer drug resistanceColorectal cancer
ISSN
1424-8247
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/ph14020136
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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