New polyenes from the marine-derived fungus Talaromyces cyanescens with anti-neuroinflammatory and cytotoxic activities

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Title
New polyenes from the marine-derived fungus Talaromyces cyanescens with anti-neuroinflammatory and cytotoxic activities
Author(s)
H J Shin; C V Anh; D Y Cho; D K Choi; Jong Soon Kang; P T H Trinh; B K Choi; H S Lee
Bibliographic Citation
Molecules, vol. 26, no. 4, pp. 836-836
Publication Year
2021
Abstract
Three new polyene compounds, talacyanols A-C (1-3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1-5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher’s methods, as well as comparison with previously reported literature data. All the compounds (1?5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.
Keyword
Talaromyces cyanescensMarine-derived fungusPolyenesCytotoxicityAnti-neuroinflammatory
ISSN
1420-3049
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/molecules26040836
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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