Pheophorbide a derivatives exert antiwrinkle effects on UVB-induced skin aging in human fibroblasts

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dc.contributor.authorHwa Lee-
dc.contributor.authorHo Yong Park-
dc.contributor.authorTae Sook Jeong-
dc.date.accessioned2021-02-19T03:31:13Z-
dc.date.available2021-02-19T03:31:13Z-
dc.date.issued2021-
dc.identifier.issn2075-1729-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24102-
dc.description.abstractPheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (UV) B-stimulated CCD-986sk fibroblasts. PA, PyroPA, and PyroPA-ME effectively suppressed reactive oxygen species accumulation in UVB-exposed CCD-986sk fibroblasts. All three pheophorbides also reduced UVB-induced matrix metalloproteinase (MMP)-1 secretion and mRNA expression of MMP-1, MMP-2, and MMP-9. Treatment with pheophorbides resulted in increased procollagen synthesis, and this required enhancement of procollagen type I C-peptide content and mRNA expression of collagen type I alpha 1 (COL1A1) and COL1A2 in CCD-986sk cells. These antiwrinkle effects were more potent with PA and PyroPA than with PyroPA-ME. Furthermore, PA and PyroPA suppressed UVB-induced phosphorylation of extracellular signal-regulated protein kinase and c-Jun N-terminal kinase but not p38. Moreover, all three pheophorbides inhibited NF-κB p65 phosphorylation. Therefore, these pheophorbides, especially PA and PyroPA, can be used as antiwrinkle agents, and PA- or PyroPA-rich natural resources can be used in functional cosmetics.-
dc.publisherMDPI-
dc.titlePheophorbide a derivatives exert antiwrinkle effects on UVB-induced skin aging in human fibroblasts-
dc.title.alternativePheophorbide a derivatives exert antiwrinkle effects on UVB-induced skin aging in human fibroblasts-
dc.typeArticle-
dc.citation.titleLife-Basel-
dc.citation.number2-
dc.citation.endPage147-
dc.citation.startPage147-
dc.citation.volume11-
dc.contributor.affiliatedAuthorHwa Lee-
dc.contributor.affiliatedAuthorHo Yong Park-
dc.contributor.affiliatedAuthorTae Sook Jeong-
dc.contributor.alternativeName이화-
dc.contributor.alternativeName박호용-
dc.contributor.alternativeName정태숙-
dc.identifier.bibliographicCitationLife-Basel, vol. 11, no. 2, pp. 147-147-
dc.identifier.doi10.3390/life11020147-
dc.subject.keywordAntiwrinkle-
dc.subject.keywordCollagen-
dc.subject.keywordFibroblasts-
dc.subject.keywordPheophorbide a derivatives-
dc.subject.keywordMatrix metalloproteinases-
dc.subject.localanti-wrinkle-
dc.subject.localAntiwrinkle-
dc.subject.localAnti-wrinkle-
dc.subject.localCollagen-
dc.subject.localcollagen-
dc.subject.localfibroblasts-
dc.subject.localfibroblast-
dc.subject.localFibroblasts-
dc.subject.localPheophorbide a derivatives-
dc.subject.localMatrix metalloproteinases-
dc.subject.localmatrix metalloproteinase-
dc.subject.localMatrix metalloproteinase-
dc.subject.localmatrix metalloproteinases-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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