DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwa Lee | - |
dc.contributor.author | Ho Yong Park | - |
dc.contributor.author | Tae Sook Jeong | - |
dc.date.accessioned | 2021-02-19T03:31:13Z | - |
dc.date.available | 2021-02-19T03:31:13Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2075-1729 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/24102 | - |
dc.description.abstract | Pheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (UV) B-stimulated CCD-986sk fibroblasts. PA, PyroPA, and PyroPA-ME effectively suppressed reactive oxygen species accumulation in UVB-exposed CCD-986sk fibroblasts. All three pheophorbides also reduced UVB-induced matrix metalloproteinase (MMP)-1 secretion and mRNA expression of MMP-1, MMP-2, and MMP-9. Treatment with pheophorbides resulted in increased procollagen synthesis, and this required enhancement of procollagen type I C-peptide content and mRNA expression of collagen type I alpha 1 (COL1A1) and COL1A2 in CCD-986sk cells. These antiwrinkle effects were more potent with PA and PyroPA than with PyroPA-ME. Furthermore, PA and PyroPA suppressed UVB-induced phosphorylation of extracellular signal-regulated protein kinase and c-Jun N-terminal kinase but not p38. Moreover, all three pheophorbides inhibited NF-κB p65 phosphorylation. Therefore, these pheophorbides, especially PA and PyroPA, can be used as antiwrinkle agents, and PA- or PyroPA-rich natural resources can be used in functional cosmetics. | - |
dc.publisher | MDPI | - |
dc.title | Pheophorbide a derivatives exert antiwrinkle effects on UVB-induced skin aging in human fibroblasts | - |
dc.title.alternative | Pheophorbide a derivatives exert antiwrinkle effects on UVB-induced skin aging in human fibroblasts | - |
dc.type | Article | - |
dc.citation.title | Life-Basel | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 147 | - |
dc.citation.startPage | 147 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Hwa Lee | - |
dc.contributor.affiliatedAuthor | Ho Yong Park | - |
dc.contributor.affiliatedAuthor | Tae Sook Jeong | - |
dc.contributor.alternativeName | 이화 | - |
dc.contributor.alternativeName | 박호용 | - |
dc.contributor.alternativeName | 정태숙 | - |
dc.identifier.bibliographicCitation | Life-Basel, vol. 11, no. 2, pp. 147-147 | - |
dc.identifier.doi | 10.3390/life11020147 | - |
dc.subject.keyword | Antiwrinkle | - |
dc.subject.keyword | Collagen | - |
dc.subject.keyword | Fibroblasts | - |
dc.subject.keyword | Pheophorbide a derivatives | - |
dc.subject.keyword | Matrix metalloproteinases | - |
dc.subject.local | anti-wrinkle | - |
dc.subject.local | Antiwrinkle | - |
dc.subject.local | Anti-wrinkle | - |
dc.subject.local | Collagen | - |
dc.subject.local | collagen | - |
dc.subject.local | fibroblasts | - |
dc.subject.local | fibroblast | - |
dc.subject.local | Fibroblasts | - |
dc.subject.local | Pheophorbide a derivatives | - |
dc.subject.local | Matrix metalloproteinases | - |
dc.subject.local | matrix metalloproteinase | - |
dc.subject.local | Matrix metalloproteinase | - |
dc.subject.local | matrix metalloproteinases | - |
dc.description.journalClass | Y | - |
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