TXNIP regulates natural killer cell-mediated innate immunity by inhibiting IFN-γ production during bacterial infection

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dc.contributor.authorD O Kim-
dc.contributor.authorJae Eun Byun-
dc.contributor.authorWon Sam Kim-
dc.contributor.authorM J Kim-
dc.contributor.authorJung Ha Choi-
dc.contributor.authorHanna Kim-
dc.contributor.authorEunji Choi-
dc.contributor.authorTae-Don Kim-
dc.contributor.authorSuk Ran Yoon-
dc.contributor.authorJi Yoon Noh-
dc.contributor.authorYoung-Jun Park-
dc.contributor.authorJungwoon Lee-
dc.contributor.authorHee Jun Cho-
dc.contributor.authorHee Gu Lee-
dc.contributor.authorS H Min-
dc.contributor.authorInpyo Choi-
dc.contributor.authorHaiyoung Jung-
dc.date.accessioned2021-02-26T08:33:09Z-
dc.date.available2021-02-26T08:33:09Z-
dc.date.issued2020-
dc.identifier.issn16616596-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24137-
dc.description.abstractThe function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability of innate immune cells. Here, we identified the critical role of thioredoxin-interacting protein (TXNIP) in the production of IFN-γ in NK cells during bacterial infection. TXNIP inhibited the production of IFN-γ and the activation of transforming growth factor β-activated kinase 1 (TAK1) activity in primary mouse and human NK cells. TXNIP directly interacted with TAK1 and inhibited TAK1 activity by interfering with the complex formation between TAK1 and TAK1 binding protein 1 (TAB1). Txnip?/? (KO) NK cells enhanced the activation of macrophages by inducing IFN-γ production during Pam3CSK4 stimulation or Staphylococcus aureus (S. aureus) infection and contributed to expedite the bacterial clearance. Our findings suggest that NK cell-derived IFN-γ is critical for host defense and that TXNIP plays an important role as an inhibitor of NK cell-mediated macrophage activation by inhibiting the production of IFN-γ during bacterial infection.-
dc.publisherMDPI-
dc.titleTXNIP regulates natural killer cell-mediated innate immunity by inhibiting IFN-γ production during bacterial infection-
dc.title.alternativeTXNIP regulates natural killer cell-mediated innate immunity by inhibiting IFN-γ production during bacterial infection-
dc.typeArticle-
dc.citation.titleInternational Journal of Molecular Sciences-
dc.citation.number24-
dc.citation.endPage9499-
dc.citation.startPage9499-
dc.citation.volume21-
dc.contributor.affiliatedAuthorJae Eun Byun-
dc.contributor.affiliatedAuthorWon Sam Kim-
dc.contributor.affiliatedAuthorJung Ha Choi-
dc.contributor.affiliatedAuthorHanna Kim-
dc.contributor.affiliatedAuthorEunji Choi-
dc.contributor.affiliatedAuthorTae-Don Kim-
dc.contributor.affiliatedAuthorSuk Ran Yoon-
dc.contributor.affiliatedAuthorJi Yoon Noh-
dc.contributor.affiliatedAuthorYoung-Jun Park-
dc.contributor.affiliatedAuthorJungwoon Lee-
dc.contributor.affiliatedAuthorHee Jun Cho-
dc.contributor.affiliatedAuthorHee Gu Lee-
dc.contributor.affiliatedAuthorInpyo Choi-
dc.contributor.affiliatedAuthorHaiyoung Jung-
dc.contributor.alternativeName김동오-
dc.contributor.alternativeName변재은-
dc.contributor.alternativeName김원삼-
dc.contributor.alternativeName김미정-
dc.contributor.alternativeName최정하-
dc.contributor.alternativeName김한나-
dc.contributor.alternativeName최은지-
dc.contributor.alternativeName김태돈-
dc.contributor.alternativeName윤석란-
dc.contributor.alternativeName노지윤-
dc.contributor.alternativeName박영준-
dc.contributor.alternativeName이정운-
dc.contributor.alternativeName조희준-
dc.contributor.alternativeName이희구-
dc.contributor.alternativeName민상현-
dc.contributor.alternativeName최인표-
dc.contributor.alternativeName정해용-
dc.identifier.bibliographicCitationInternational Journal of Molecular Sciences, vol. 21, no. 24, pp. 9499-9499-
dc.identifier.doi10.3390/ijms21249499-
dc.subject.keywordNK cell-
dc.subject.keywordIFN-γ-
dc.subject.keywordTXNIP-
dc.subject.keywordTAK1-
dc.subject.keywordToll-like receptor (TLR)-
dc.subject.keywordBacterial infection-
dc.subject.localNK cell-
dc.subject.localIFN-γ-
dc.subject.localTXNIP-
dc.subject.localTAK1-
dc.subject.localBacterial infection-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
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