Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

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Title
Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood
Author(s)
Jieun Kim; Hyebin Koh; X Zhen; D S Lee; H Y Ha; JONG-HEE LEE
Bibliographic Citation
Stem Cell Research, vol. 51, pp. 102199-102199
Publication Year
2021
Abstract
Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD-) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD- sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD- somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.
ISSN
1873-5061
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.scr.2021.102199
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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