A new surface charge neutralizing nano-adjuvant to potentiate polymyxins in killing Mcr-1 mediated drug-resistant Escherichia coli

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dc.contributor.authorH Cho-
dc.contributor.authorA Naskar-
dc.contributor.authorS Lee-
dc.contributor.authorSemi Kim-
dc.contributor.authorK S Kim-
dc.date.accessioned2021-03-09T03:30:49Z-
dc.date.available2021-03-09T03:30:49Z-
dc.date.issued2021-
dc.identifier.issn19994923-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24165-
dc.description.abstractResistance to polymyxins when treating multidrug-resistant (MDR) Gram-negative bacterial infections limit therapeutic options. Here, we report the synthesis of a nickel (Ni) doped Zinc oxide (NZO) combined with black phosphorus (BP) (NZB) nanocomposite and its synergistic action with polymyxin B (PolB) against polymyxin-resistant Escherichia coli harboring mobilized colistin resistance (mcr-1) gene. NZB and PolB combination therapy expressed a specific and strong synergy against Mcr-1 expressing E. coli cells. The underlying mechanism of the synergy is the charge neutralization of the E. coli cell surface by NZB, resulting in a more feasible incorporation of PolB to E. coli. The synergistic concentration of NZB with PolB was proved biocompatible. Thus, the NZB is the first biocompatible nano-adjuvant to polymyxins against polymyxin-resistant E. coli cells, recognizing the physical status of bacteria instead of known adjuvants targeting cellular gene products. Therefore, NZB has the potential to revive polymyxins as leading last-resort antibiotics to combat polymyxin-resistant Gram-negative bacterial infections.-
dc.publisherMDPI-
dc.titleA new surface charge neutralizing nano-adjuvant to potentiate polymyxins in killing Mcr-1 mediated drug-resistant Escherichia coli-
dc.title.alternativeA new surface charge neutralizing nano-adjuvant to potentiate polymyxins in killing Mcr-1 mediated drug-resistant Escherichia coli-
dc.typeArticle-
dc.citation.titlePharmaceutics-
dc.citation.number2-
dc.citation.endPage250-
dc.citation.startPage250-
dc.citation.volume13-
dc.contributor.affiliatedAuthorSemi Kim-
dc.contributor.alternativeName조혜진-
dc.contributor.alternativeNameNaskar-
dc.contributor.alternativeName이소희-
dc.contributor.alternativeName김세미-
dc.contributor.alternativeName김광선-
dc.identifier.bibliographicCitationPharmaceutics, vol. 13, no. 2, pp. 250-250-
dc.identifier.doi10.3390/pharmaceutics13020250-
dc.subject.keywordNano-antibiotics-
dc.subject.keywordBlack phosphorus-
dc.subject.keywordPolymyxin-resistant Gram-negative bacteria-
dc.subject.keywordCharge neutralization mechanism-
dc.subject.keywordMcr-1-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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