HMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cells

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dc.contributor.authorH Y Song-
dc.contributor.authorWoo Sik Kim-
dc.contributor.authorJ M Han-
dc.contributor.authorW Y Park-
dc.contributor.authorS T Lim-
dc.contributor.authorE B Byun-
dc.date.accessioned2021-03-16T03:31:18Z-
dc.date.available2021-03-16T03:31:18Z-
dc.date.issued2021-
dc.identifier.issn1567-5769-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24179-
dc.description.abstractAlthough we previously identified a new hydroxymethoxyl chrysin derivative (HMOC) using ionizing radiation, the anti-inflammatory mechanism of HMOC in dendritic cells remains unclear. In this study, we investigate the effects of HMOC on phenotypic and functional changes in activated bone marrow-derived dendritic cells (BMDCs). In lipopolysaccharide (LPS)-stimulated BMDCs, HMOC treatment inhibited pro-inflammatory cytokines (TNF-α, IL-12p70, and IL-1β), surface molecules (CD80, CD86, MHC-I, and MHC-II), and antigen-presentation to MHC-I and II without a decrease in IL-10. Furthermore, HMOC increased indoleamine 2,3-dioxygenase-1 (IDO1) activity via activation of JNK and p38 signaling in the presence of LPS. Interestingly, LPS-stimulated DCs treated with HMOC inhibited the proliferation and activation of CD4+ and CD8+ T cells, as well as differentiation of CD4+ T cells into Th1-, Th2- and Th17 cells. In addition, LPS-stimulated DCs treated with HMOC induced an increase in CD4+CD25+Foxp3+ regulatory T cells (Tregs). Collectively, our results suggest that HMOC confers tolerogenic properties in BMDCs, which are responsible for inducing Th cell differentiation to Tregs. Our findings provide a better understanding of the anti-inflammatory mechanism of HMOC in DCs and may contribute to development of a valuable therapeutic candidate for atopic dermatitis.-
dc.publisherElsevier-
dc.titleHMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cells-
dc.title.alternativeHMOC, a chrysin derivative, induces tolerogenic properties in lipopolysaccharide-stimulated dendritic cells-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number0-
dc.citation.endPage107523-
dc.citation.startPage107523-
dc.citation.volume95-
dc.contributor.affiliatedAuthorWoo Sik Kim-
dc.contributor.alternativeName송하연-
dc.contributor.alternativeName김우식-
dc.contributor.alternativeName한정무-
dc.contributor.alternativeName박우용-
dc.contributor.alternativeName임승택-
dc.contributor.alternativeName변의백-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 95, pp. 107523-107523-
dc.identifier.doi10.1016/j.intimp.2021.107523-
dc.subject.keywordTolerogenic dendritic cells-
dc.subject.keywordRegulatory T cells-
dc.subject.keywordChrysin derivative-
dc.subject.keywordIndoleamine 2-
dc.subject.keyword3-Dioxygenase-
dc.subject.localTolerogenic dendritic cells-
dc.subject.localRegulatory T cells-
dc.subject.localChrysin derivative-
dc.subject.localIndoleamine 2-
dc.subject.local3-Dioxygenase-
dc.subject.local3-dioxygenase-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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