Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway

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dc.contributor.authorTae Jun Park-
dc.contributor.authorAnna Park-
dc.contributor.authorJ Kim-
dc.contributor.authorJ Y Kim-
dc.contributor.authorBaek Soo Han-
dc.contributor.authorKyoung-Jin Oh-
dc.contributor.authorEun-Woo Lee-
dc.contributor.authorSang Chul Lee-
dc.contributor.authorKwang-Hee Bae-
dc.contributor.authorWon Kon Kim-
dc.date.accessioned2021-03-17T03:30:46Z-
dc.date.available2021-03-17T03:30:46Z-
dc.date.issued2021-
dc.identifier.issn19766696-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24181-
dc.description.abstractIn current times, obesity is a major health problem closely associated with metabolic disease such as diabetes, dyslipidemia, and cardiovascular disease. The direct cause of obesity is known as an abnormal increase in fat cell size and the adipocyte pool. Hyperplasia, the increase in number of adipocytes, results from adipogenesis in which preadipocytes differentiate into mature adipocytes. Adipogenesis is regulated by local and systemic cues that alter transduction pathways and subsequent control of adipogenic transcription factors. Therefore, the regulation of adipogenesis is an important target for preventing obesity. Myo-nectin, a member of the CTRP family, is a type of myokine released by skeletal muscle cells. Although several studies have shown that myonectin is associated with lipid metabolism, the role of myonectin during adipogenesis is not known. Here, we demonstrate the role of myonectin during adipocyte differentiation of 3T3-L1 cells. We found that myonectin inhibits the adipogenesis of 3T3-L1 preadipocytes with a reduction in the expression of adipogenic transcription factors such as C/EBPα, β and PPARγ. Furthermore, we show that myonectin has an inhibitory effect on adipogenesis through the regulation of the p38 MAPK pathway and CHOP. These findings suggest that myonectin may be a novel therapeutic target for the prevention of obesity.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleMyonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway-
dc.title.alternativeMyonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number2-
dc.citation.endPage129-
dc.citation.startPage124-
dc.citation.volume54-
dc.contributor.affiliatedAuthorTae Jun Park-
dc.contributor.affiliatedAuthorAnna Park-
dc.contributor.affiliatedAuthorBaek Soo Han-
dc.contributor.affiliatedAuthorKyoung-Jin Oh-
dc.contributor.affiliatedAuthorEun-Woo Lee-
dc.contributor.affiliatedAuthorSang Chul Lee-
dc.contributor.affiliatedAuthorKwang-Hee Bae-
dc.contributor.affiliatedAuthorWon Kon Kim-
dc.contributor.alternativeName박태준-
dc.contributor.alternativeName박안나-
dc.contributor.alternativeName김재훈-
dc.contributor.alternativeName김정윤-
dc.contributor.alternativeName한백수-
dc.contributor.alternativeName오경진-
dc.contributor.alternativeName이은우-
dc.contributor.alternativeName이상철-
dc.contributor.alternativeName배광희-
dc.contributor.alternativeName김원곤-
dc.identifier.bibliographicCitationBMB Reports, vol. 54, no. 2, pp. 124-129-
dc.identifier.doi10.5483/BMBRep.2021.54.2.262-
dc.subject.keywordAdipogenesis-
dc.subject.keywordMyonection-
dc.subject.keywordp38 MAPK pathway-
dc.subject.keywordCHOP-
dc.subject.keywordObesity-
dc.subject.localAdipogenesis-
dc.subject.localCHOP-
dc.subject.localObesity-
dc.description.journalClassY-
Appears in Collections:
Division of Research on National Challenges > Biodefense Research Center > 1. Journal Articles
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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