DC Field | Value | Language |
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dc.contributor.author | Lifang Wang | - |
dc.contributor.author | H S Choi | - |
dc.contributor.author | Binna Lee | - |
dc.contributor.author | Jong Hyun Choi | - |
dc.contributor.author | Y S Jang | - |
dc.contributor.author | Jeong-Woo Seo | - |
dc.date.accessioned | 2021-03-19T03:30:20Z | - |
dc.date.available | 2021-03-19T03:30:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/24188 | - |
dc.description.abstract | Breast cancer is a major health problem worldwide. Cancer stem cells (CSCs) are known to mediate breast cancer metastasis and recurrence and are therefore a promising therapeutic target. In this study, we investigated the anti-inflammatory effect of 13R,20-dihydroxydocosahexaenoic acid (13R,20-diHDHA), a novel dihydroxy-DHA derivative, which was synthesized through an enzymatic reaction using cyanobacterial lipoxygenase. We found that 13R,20-diHDHA reduced the macrophage secretion of the inflammatory cytokines, IL-6 and TNF-α, and thus appeared to have anti-inflammatory effects. As the inflammatory tumor microenvironment is largely devoted to supporting the cancer stemness of breast cancer cells, we investigated the effect of 13R,20-diHDHA on breast cancer stemness. Indeed, 13R,20-diHDHA effectively inhibited breast cancer stemness, as evidenced by its ability to dose-dependently inhibit the mammospheres formation, colony formation, migration, and invasion of breast CSCs. 13R,20-diHDHA reduced the populations of CD44high/CD24low and aldehyde dehydrogenase (ALDH)-positive cells and the expression levels of the cancer stemness-related self-renewal genes, Nanog, Sox2, Oct4, c-Myc, and CD44. 13R,20-diHDHA increased reactive oxygen species (ROS) production, and the generated ROS reduced the phosphorylation of nuclear signal transducer and activator of transcription 3 (Stat3) and the secretion of IL-6 by mammospheres. These data collectively suggest that 13R,20-diHDHA inhibits breast cancer stemness through ROS production and downstream regulation of Stat3/IL-6 signaling, and thus might be developed as an anti-cancer agent acting against CSCs. | - |
dc.publisher | MDPI | - |
dc.title | 13R,20-dihydroxydocosahexaenoic acid, a novel dihydroxy-DHA derivative, inhibits breast cancer stemness through regulation of the Stat3/IL-6 signaling pathway by inducing ROS production = PUFA 대사체 13R,20-dH DHA의 ROS-STAT3 신호전달계를 통한 cancer stemness 제어 | - |
dc.title.alternative | 13R,20-dihydroxydocosahexaenoic acid, a novel dihydroxy-DHA derivative, inhibits breast cancer stemness through regulation of the Stat3/IL-6 signaling pathway by inducing ROS production | - |
dc.type | Article | - |
dc.citation.title | Antioxidants | - |
dc.citation.number | 3 | - |
dc.citation.endPage | 457 | - |
dc.citation.startPage | 457 | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Lifang Wang | - |
dc.contributor.affiliatedAuthor | Binna Lee | - |
dc.contributor.affiliatedAuthor | Jong Hyun Choi | - |
dc.contributor.affiliatedAuthor | Jeong-Woo Seo | - |
dc.contributor.alternativeName | 왕리팡 | - |
dc.contributor.alternativeName | 최학선 | - |
dc.contributor.alternativeName | 이빛나 | - |
dc.contributor.alternativeName | 최종현 | - |
dc.contributor.alternativeName | 장용석 | - |
dc.contributor.alternativeName | 서정우 | - |
dc.identifier.bibliographicCitation | Antioxidants, vol. 10, no. 3, pp. 457-457 | - |
dc.identifier.doi | 10.3390/antiox10030457 | - |
dc.subject.keyword | Breast cancer stem cells | - |
dc.subject.keyword | 13R,20-dihydroxydocosahexaenoic acid (13R,20-diHDHA) | - |
dc.subject.keyword | Mammospheres | - |
dc.subject.keyword | ROS | - |
dc.subject.keyword | Stat3 | - |
dc.subject.local | Breast cancer stem cells | - |
dc.subject.local | 13R,20-dihydroxydocosahexaenoic acid (13R,20-diHDHA) | - |
dc.subject.local | Mammospheres | - |
dc.subject.local | Reactive oxidative species | - |
dc.subject.local | Reactive oxygen species(ROS) | - |
dc.subject.local | Reactive oxygen species | - |
dc.subject.local | Reactive Oxygen Species (ROS) | - |
dc.subject.local | Reactive Oxygen Species | - |
dc.subject.local | ROS | - |
dc.subject.local | Reactive oxygen species (ROS) | - |
dc.subject.local | reactive oxygen species | - |
dc.subject.local | reactive oxygen species (ROS) | - |
dc.subject.local | Signal transducer and activator of transcription 3 (STAT3) | - |
dc.subject.local | Signal transducer and activator of transcription | - |
dc.subject.local | Signal transducer and activator of transcription 3 (Stat3) | - |
dc.subject.local | STAT 3 | - |
dc.subject.local | STAT3 | - |
dc.subject.local | Signal transducer and activator of transcription 3 | - |
dc.subject.local | Stat3 | - |
dc.subject.local | Signal transducer and activator of transcription factor 3 (STAT3) | - |
dc.description.journalClass | Y | - |
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