Current status of COVID-19 vaccine development: focusing on antigen design and clinical trials on later stages

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Title
Current status of COVID-19 vaccine development: focusing on antigen design and clinical trials on later stages
Author(s)
Pureum Lee; Chang-Ung Kim; S H Seo; Doo-Jin Kim
Bibliographic Citation
Immune Network, vol. 21, no. 1, pp. e4-e4
Publication Year
2021
Abstract
The global outbreak of coronavirus disease 2019 (COVID-19) is still threatening human health, economy, and social life worldwide. As a counteraction for this devastating disease, a number of vaccines are being developed with unprecedented speed combined with new technologies. As COVID-19 vaccines are being developed in the absence of a licensed human coronavirus vaccine, there remain further questions regarding the long-term efficacy and safety of the vaccines, as well as immunological mechanisms in depth. This review article discusses the current status of COVID-19 vaccine development, mainly focusing on antigen design, clinical trials in later stages, and immunological considerations for further study.
Keyword
COVID-19VaccinesPrefusion-stabilizedVAERDAntibody-dependent enhancementPre-existing immunological memory
ISSN
1598-2629
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4110/in.2021.21.e4
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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