Immunoregulatory properties of a crude extraction fraction rich in polysaccharide from Chrysanthemum zawadskii Herbich var. latilobum and its potential role as a vaccine adjuvant

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dc.contributor.authorJ M Han-
dc.contributor.authorH Y Song-
dc.contributor.authorH S Seo-
dc.contributor.authorE H Byun-
dc.contributor.authorS T Lim-
dc.contributor.authorWoo Sik Kim-
dc.contributor.authorE B Byun-
dc.date.accessioned2021-03-25T03:30:23Z-
dc.date.available2021-03-25T03:30:23Z-
dc.date.issued2021-
dc.identifier.issn1567-5769-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24193-
dc.description.abstractThe objective of the current study was to demonstrate the immunostimulatory effects of a polysaccharide isolated from Chrysanthemum zawadskii Herbich var. latilobum leaves (CP) and evaluate its potential as a vaccine adjuvant. Results showed that CP induced maturation of the dendritic cells (DCs). In addition, CP-treated DCs activated naive T cells to polarized CD4+ and CD8+ T cells and substantially induced the production of IFN-γ and IL-2 in vitro. Furthermore, CP initiated the maturation of DCs via the activation of MAPK and NF-κB signaling pathways. Interestingly, systemic administration of CP-treated DCs pulsed with ovalbumin (OVA) peptides significantly enhanced the immune response in vivo, which included the generation of antigen (OVA)-specific polyfunctional T cells, increased cytotoxic T lymphocyte activity, induction of Th1-mediated humoral immunity, and suppression of tumor growth. Taken together, our study highlighted the immunoregulatory activity of CP as well as its potential as a candidate vaccine adjuvant.-
dc.publisherElsevier-
dc.titleImmunoregulatory properties of a crude extraction fraction rich in polysaccharide from Chrysanthemum zawadskii Herbich var. latilobum and its potential role as a vaccine adjuvant-
dc.title.alternativeImmunoregulatory properties of a crude extraction fraction rich in polysaccharide from Chrysanthemum zawadskii Herbich var. latilobum and its potential role as a vaccine adjuvant-
dc.typeArticle-
dc.citation.titleInternational Immunopharmacology-
dc.citation.number0-
dc.citation.endPage107513-
dc.citation.startPage107513-
dc.citation.volume95-
dc.contributor.affiliatedAuthorWoo Sik Kim-
dc.contributor.alternativeName한정무-
dc.contributor.alternativeName송하연-
dc.contributor.alternativeName서호성-
dc.contributor.alternativeName변의홍-
dc.contributor.alternativeName임승택-
dc.contributor.alternativeName김우식-
dc.contributor.alternativeName변의백-
dc.identifier.bibliographicCitationInternational Immunopharmacology, vol. 95, pp. 107513-107513-
dc.identifier.doi10.1016/j.intimp.2021.107513-
dc.subject.keywordNatural product-
dc.subject.keywordChrysanthemum zawadskii Herbich var.-
dc.subject.keywordLatilobum-
dc.subject.keywordDendritic cell-
dc.subject.keywordAnti-tumor immunity-
dc.subject.keywordPolyfunctional T cell-
dc.subject.keywordAdjuvant-
dc.subject.localnatural products-
dc.subject.localNatural Product-
dc.subject.localNatural products-
dc.subject.localnatural product-
dc.subject.localNatural product-
dc.subject.localChrysanthemum zawadskii Herbich var.-
dc.subject.localLatilobum-
dc.subject.localDendritic cell-
dc.subject.localDendritic cells (DC)-
dc.subject.localdendritic cells-
dc.subject.localDendritic cells (DCs)-
dc.subject.localDendritic cells-
dc.subject.localdendritic cells (DC)-
dc.subject.localdendritic cell-
dc.subject.localAntitumor immunity-
dc.subject.localAnti-tumor immunity-
dc.subject.localPolyfunctional T cell-
dc.subject.localadjuvant-
dc.subject.localAdjuvants-
dc.subject.localAdjuvant-
dc.subject.localadjuvants-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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