Diacylglycerol acyltransferase inhibitory new meroterpenes from the seeds of Psoralea corylifolia, and their structure-activity relationship study

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Title
Diacylglycerol acyltransferase inhibitory new meroterpenes from the seeds of Psoralea corylifolia, and their structure-activity relationship study
Author(s)
M X Xiu; Y M Zhao; Y Zhang; D X Xiong; D Wang; Hyun Sun Lee; L Cui
Bibliographic Citation
Fitoterapia, vol. 151, pp. 104881-104881
Publication Year
2021
Abstract
Five new meroterpenes, 12α-Psoracorylifol F (1), 7β,8α-hydroxy-12β-Psoracorylifol F (2), 8-ketone-Cyclobakuchiol C (3), 7α,8β-hydroxy-12β-Cyclobakuchiol C (4) and 8α-hydroxy-Cyclobakuchiol C (5) together with six known compounds (6-11) were isolated from seeds of Psoralea corylifolia, and their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1/2. Among them, compounds 1-6 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 61.5 ± 1.1 to 89.1 ± 1.2 μM.
Keyword
Psoralea corylifoliaMeroterpenesDGATInhibitory
ISSN
0367-326X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.fitote.2021.104881
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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