Lipid metabolism and ferroptosis

Cited 3 time in scopus
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Title
Lipid metabolism and ferroptosis
Author(s)
Ji-Yoon Lee; Won Kon KimKwang-Hee BaeSang Chul LeeEun-Woo Lee
Bibliographic Citation
Biology-Basel, vol. 10, no. 3, pp. 184-184
Publication Year
2021
Abstract
Ferroptosis is a type of iron-dependent regulated necrosis induced by lipid peroxidation that occurs in cellular membranes. Among the various lipids, polyunsaturated fatty acids (PUFAs) associated with several phospholipids, such as phosphatidylethanolamine (PE) and phosphatidylcholine (PC), are responsible for ferroptosis-inducing lipid peroxidation. Since the de novo synthesis of PUFAs is strongly restricted in mammals, cells take up essential fatty acids from the blood and lymph to produce a variety of PUFAs via PUFA biosynthesis pathways. Free PUFAs can be incorporated into the cellular membrane by several enzymes, such as ACLS4 and LPCAT3, and undergo lipid peroxidation through enzymatic and non-enzymatic mechanisms. These pathways are tightly regulated by various metabolic and signaling pathways. In this review, we summarize our current knowledge of how various lipid metabolic pathways are associated with lipid peroxidation and ferroptosis. Our review will provide insight into treatment strategies for ferroptosis-related diseases.
Keyword
FerroptosisLipid peroxidationPolyunsaturated fatty acidsGPX4Lipoxygenase
ISSN
2079-7737
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/biology10030184
Type
Article
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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