Gene expression in the striatum of cynomolgus monkeys after chronic administration of cocaine and heroin

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Title
Gene expression in the striatum of cynomolgus monkeys after chronic administration of cocaine and heroin
Author(s)
M R Choi; Yeung Bae Jin; Han Na Kim; Y G Chai; C N Im; Sang-Rae Lee; D J Kim
Bibliographic Citation
Basic & Clinical Pharmacology & Toxicology, vol. 128, no. 5, pp. 686-698
Publication Year
2021
Abstract
Cocaine and heroin cause impairment of neural plasticity in the brain including striatum. This study aimed to identify genes differentially expressed in the striatum of cynomolgus monkeys in response to cocaine and heroin. After chronic administration of cocaine and heroin in the monkeys, we performed large-scale transcriptome profiling in the striatum using RNA-Seq technology and analysed functional annotation. We found that 547 and 1238 transcripts were more than 1.5-fold up- or down-regulated in cocaine- and heroin-treated groups, respectively, compared to the control group, and 3432 transcripts exhibited differential expression between cocaine- and heroin-treated groups. Functional annotation analysis indicated that genes associated with nervous system development (NAGLU, MOBP and TTL7) and stress granule disassembly (KIF5B and KLC1) were differentially expressed in the cocaine-treated group compared to the control group, whereas gene associated with neuron apoptotic process (ERBB3) was differentially expressed in the heroin-treated group. In addition, IPA network analysis indicated that genes (TRAF6 and TRAF3IP2) associated with inflammation were increased by the chronic administration of cocaine and heroin. These results provide insight into the correlated molecular mechanisms as well as the upregulation and down-regulation of genes in the striatum after chronic exposure to cocaine and heroin.
Keyword
CocaineGene expression profilingHeroinNon-human primateStriatum
ISSN
1742-7835
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/bcpt.13554
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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