Development of a cosmetic ingredient containing DHA derivatives for anti-inflammation, anti-wrinkle, and improvement of skin barrier function = DHA 유도체를 이용한 함염, 항노화, 피부장벽 강화용 화장품 원료의 개발

Cited 0 time in scopus
Metadata Downloads
Title
Development of a cosmetic ingredient containing DHA derivatives for anti-inflammation, anti-wrinkle, and improvement of skin barrier function = DHA 유도체를 이용한 함염, 항노화, 피부장벽 강화용 화장품 원료의 개발
Author(s)
M Lee; G Y Lee; J Suh; K M Lee; W Lee; H W Cho; Jong-Jae Yi; Jeong-Woo Seo; H Choi
Bibliographic Citation
Journal of Society of Cosmetic Scientists of Korea, vol. 47, no. 1, pp. 65-73
Publication Year
2021
Abstract
It is very important to control the inflammation of the skin because it can develop into diseases such as atopy as well as scarring and aging. In this work, we recently identified the in vitro synthesis of specialized pro-resolving mediators (SPMs) known to control inflammation in the human body and the applicability of cosmetics. Using recombinant protein of lipoxygenase from Glycine max, we succeeded to prepare mixtures of mono- or di-hydroxy DHA named as S-SPMs and used them for in vitro efficacy test. To investigate anti-inflammatory effect of S-SPMs, mRNA level of TNF-α and IL-6 were analyzed. Under UVB exposed condition, expression of both were decreased by S-SPMs treatment. And we observed reduced production of nitric oxide (NO) by S-SPMs application under the condition with diesel particulate matter (DPM). At the same experimental condition, malondialdehyde (MDA) production was decreased by S-SPMs, indicating the inhibitory effect of S-SPMs in lipid peroxidation. In addition, S-SPMs treatment resulted in reduction of matrix metalloproteinases-1 (MMP-1) expression and elevation of procollagen type I synthesis. Together with this, mRNA level of filaggrin and loricrin were increased by S-SPMs, indicating enhancement of skin barrier function. These results demonstrate that S-SPMs is a good candidate to develop as a cosmetic ingredient for anti-inflammation, anti-wrinkle, and improvement of skin barrier function.
Keyword
Specialized pro-resolving mediatorsLipoxygenaseAnti-inflammationAnti-wrinkleSkin barrier
ISSN
1226-2587
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.15230/SCSK.2021.47.1.65
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.