Modified MYOMI-14 Korean herbal formulations have protective effects against cyclophosphamide-induced male infertility in mice

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Title
Modified MYOMI-14 Korean herbal formulations have protective effects against cyclophosphamide-induced male infertility in mice
Author(s)
Arum Park; Yun Jeong Yang; J Jo; Suk Ran Yoon
Bibliographic Citation
Andrologia, vol. 53, no. 5, pp. e14025-e14025
Publication Year
2021
Abstract
Korean herbal formulation, MYOMI-14, has been reported to improve the idiopathic male infertility condition with poor semen. In this study, four MYOMI formulations were modified from MYOMI-14 by reducing the number of constituents. We investigated the therapeutic effect of MYOMI formulations on cyclophosphamide-induced male infertility using mice model. Cyclophosphamide treatment significantly decreased body weight, testicular weight, sperm count, normal-shaped sperm rate and sperm motility compared to untreated control group, whereas MYOMI formulations restore the cyclophosphamide-induced dysfunction, as determined by increased sperm count and motility, and decreased abnormally shaped spermatozoa. In addition, treatment with MYOMI formulations reduced cyclophosphamide-induced apoptosis of germ cells and oxidative stress. MYOMI-treated mice also showed improved spermatogenesis as shown by the increased expression of spermatogenesis-related genes, as cAMP-responsive element modulator (CREM) and cAMP response element-binding (CREB) protein. Among the MYOMI formulations, MYOMI-7 showed better results in terms of recovering CP-induced damages to testis and improving the fertility. Taken together, this study is expected to make significant contribution to the literature by exploring various formulations that reduced constituents of MYOMI-14, a Korean herbal medicine, in treating CP-induced male infertility
Keyword
CyclophosphamideKorean herbal formulationMale infertilityMYOMI
ISSN
0303-4569
Publisher
Wiley
DOI
http://dx.doi.org/10.1111/and.14025
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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