Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates

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dc.contributor.authorS H Hong-
dc.contributor.authorHanseul Oh-
dc.contributor.authorY W Park-
dc.contributor.authorH W Kwak-
dc.contributor.authorE Y Oh-
dc.contributor.authorH J Park-
dc.contributor.authorK W Kang-
dc.contributor.authorGreen Kim-
dc.contributor.authorBon-Sang Koo-
dc.contributor.authorEun-Ha Hwang-
dc.contributor.authorSeung Ho Baek-
dc.contributor.authorH J Park-
dc.contributor.authorY S Lee-
dc.contributor.authorY J Bang-
dc.contributor.authorJ Y Kim-
dc.contributor.authorS H Bae-
dc.contributor.authorS J Lee-
dc.contributor.authorK W Seo-
dc.contributor.authorH Kim-
dc.contributor.authorT Kwon-
dc.contributor.authorS M Lee-
dc.contributor.authorJung Joo Hong-
dc.contributor.authorJ H Nam-
dc.date.accessioned2021-06-01T03:30:54Z-
dc.date.available2021-06-01T03:30:54Z-
dc.date.issued2021-
dc.identifier.issn2375-2548-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24363-
dc.description.abstractSince the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), various vaccines are being developed, with most vaccine candidates focusing on the viral spike protein. Here, we developed a previously unknown subunit vaccine comprising the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 (RBD-P2) and tested its efficacy in rodents and nonhuman primates (NHPs). We also investigated whether the SARS-CoV-2 nucleocapsid protein (N) could increase vaccine efficacy. Immunization with N and RBD-P2 (RBDP2/N) + alum increased T cell responses in mice and neutralizing antibody levels in rats compared with those obtained using RBD-P2 + alum. Furthermore, in NHPs, RBD-P2/N + alum induced slightly faster SARS-CoV-2 clearance than that induced by RBD-P2 + alum, albeit without statistical significance. Our study supports further development of RBD-P2 as a vaccine candidate against SARS-CoV-2. Also, it provides insights regarding the use of N in protein-based vaccines against SARS-CoV-2.-
dc.publisherAmer Assoc Advancement Science-
dc.titleImmunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates-
dc.title.alternativeImmunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates-
dc.typeArticle-
dc.citation.titleScience Advances-
dc.citation.number22-
dc.citation.endPageeabg7156-
dc.citation.startPageeabg7156-
dc.citation.volume7-
dc.contributor.affiliatedAuthorHanseul Oh-
dc.contributor.affiliatedAuthorGreen Kim-
dc.contributor.affiliatedAuthorBon-Sang Koo-
dc.contributor.affiliatedAuthorEun-Ha Hwang-
dc.contributor.affiliatedAuthorSeung Ho Baek-
dc.contributor.affiliatedAuthorJung Joo Hong-
dc.contributor.alternativeName홍소희-
dc.contributor.alternativeName오한슬-
dc.contributor.alternativeName박용욱-
dc.contributor.alternativeName곽혜원-
dc.contributor.alternativeName오은영-
dc.contributor.alternativeName박효정-
dc.contributor.alternativeName강경원-
dc.contributor.alternativeName김그린-
dc.contributor.alternativeName구본상-
dc.contributor.alternativeName황은하-
dc.contributor.alternativeName백승호-
dc.contributor.alternativeName박형준-
dc.contributor.alternativeName이유선-
dc.contributor.alternativeName방유진-
dc.contributor.alternativeName김재용-
dc.contributor.alternativeName배서현-
dc.contributor.alternativeName이수진-
dc.contributor.alternativeName서기원-
dc.contributor.alternativeName김학-
dc.contributor.alternativeName권태우-
dc.contributor.alternativeName이상명-
dc.contributor.alternativeName홍정주-
dc.contributor.alternativeName남재환-
dc.identifier.bibliographicCitationScience Advances, vol. 7, no. 22, pp. eabg7156-eabg7156-
dc.identifier.doi10.1126/sciadv.abg7156-
dc.description.journalClassY-
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Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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