DC Field | Value | Language |
---|---|---|
dc.contributor.author | S H Hong | - |
dc.contributor.author | Hanseul Oh | - |
dc.contributor.author | Y W Park | - |
dc.contributor.author | H W Kwak | - |
dc.contributor.author | E Y Oh | - |
dc.contributor.author | H J Park | - |
dc.contributor.author | K W Kang | - |
dc.contributor.author | Green Kim | - |
dc.contributor.author | Bon-Sang Koo | - |
dc.contributor.author | Eun-Ha Hwang | - |
dc.contributor.author | Seung Ho Baek | - |
dc.contributor.author | H J Park | - |
dc.contributor.author | Y S Lee | - |
dc.contributor.author | Y J Bang | - |
dc.contributor.author | J Y Kim | - |
dc.contributor.author | S H Bae | - |
dc.contributor.author | S J Lee | - |
dc.contributor.author | K W Seo | - |
dc.contributor.author | H Kim | - |
dc.contributor.author | T Kwon | - |
dc.contributor.author | S M Lee | - |
dc.contributor.author | Jung Joo Hong | - |
dc.contributor.author | J H Nam | - |
dc.date.accessioned | 2021-06-01T03:30:54Z | - |
dc.date.available | 2021-06-01T03:30:54Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/24363 | - |
dc.description.abstract | Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), various vaccines are being developed, with most vaccine candidates focusing on the viral spike protein. Here, we developed a previously unknown subunit vaccine comprising the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 (RBD-P2) and tested its efficacy in rodents and nonhuman primates (NHPs). We also investigated whether the SARS-CoV-2 nucleocapsid protein (N) could increase vaccine efficacy. Immunization with N and RBD-P2 (RBDP2/N) + alum increased T cell responses in mice and neutralizing antibody levels in rats compared with those obtained using RBD-P2 + alum. Furthermore, in NHPs, RBD-P2/N + alum induced slightly faster SARS-CoV-2 clearance than that induced by RBD-P2 + alum, albeit without statistical significance. Our study supports further development of RBD-P2 as a vaccine candidate against SARS-CoV-2. Also, it provides insights regarding the use of N in protein-based vaccines against SARS-CoV-2. | - |
dc.publisher | Amer Assoc Advancement Science | - |
dc.title | Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates | - |
dc.title.alternative | Immunization with RBD-P2 and N protects against SARS-CoV-2 in nonhuman primates | - |
dc.type | Article | - |
dc.citation.title | Science Advances | - |
dc.citation.number | 22 | - |
dc.citation.endPage | eabg7156 | - |
dc.citation.startPage | eabg7156 | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Hanseul Oh | - |
dc.contributor.affiliatedAuthor | Green Kim | - |
dc.contributor.affiliatedAuthor | Bon-Sang Koo | - |
dc.contributor.affiliatedAuthor | Eun-Ha Hwang | - |
dc.contributor.affiliatedAuthor | Seung Ho Baek | - |
dc.contributor.affiliatedAuthor | Jung Joo Hong | - |
dc.contributor.alternativeName | 홍소희 | - |
dc.contributor.alternativeName | 오한슬 | - |
dc.contributor.alternativeName | 박용욱 | - |
dc.contributor.alternativeName | 곽혜원 | - |
dc.contributor.alternativeName | 오은영 | - |
dc.contributor.alternativeName | 박효정 | - |
dc.contributor.alternativeName | 강경원 | - |
dc.contributor.alternativeName | 김그린 | - |
dc.contributor.alternativeName | 구본상 | - |
dc.contributor.alternativeName | 황은하 | - |
dc.contributor.alternativeName | 백승호 | - |
dc.contributor.alternativeName | 박형준 | - |
dc.contributor.alternativeName | 이유선 | - |
dc.contributor.alternativeName | 방유진 | - |
dc.contributor.alternativeName | 김재용 | - |
dc.contributor.alternativeName | 배서현 | - |
dc.contributor.alternativeName | 이수진 | - |
dc.contributor.alternativeName | 서기원 | - |
dc.contributor.alternativeName | 김학 | - |
dc.contributor.alternativeName | 권태우 | - |
dc.contributor.alternativeName | 이상명 | - |
dc.contributor.alternativeName | 홍정주 | - |
dc.contributor.alternativeName | 남재환 | - |
dc.identifier.bibliographicCitation | Science Advances, vol. 7, no. 22, pp. eabg7156-eabg7156 | - |
dc.identifier.doi | 10.1126/sciadv.abg7156 | - |
dc.description.journalClass | Y | - |
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