Jejucarbazoles A-C, Carbazole Glycosides with Indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151

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dc.contributor.authorGil Su Kim-
dc.contributor.authorJun-Pil Jang-
dc.contributor.authorMincheol Kwon-
dc.contributor.authorTae Hoon Oh-
dc.contributor.authorKyung Taek Heo-
dc.contributor.authorByeongsan Lee-
dc.contributor.authorJung-Sook Lee-
dc.contributor.authorSung-Kyun Ko-
dc.contributor.authorYoung-Soo Hong-
dc.contributor.authorJong Seog Ahn-
dc.contributor.authorJae-Hyuk Jang-
dc.date.accessioned2021-06-03T03:30:34Z-
dc.date.available2021-06-03T03:30:34Z-
dc.date.issued2021-
dc.identifier.issn20462069-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24370-
dc.description.abstractA bioassay-guided investigation led to the isolation of three new carbazole glycosides, jejucarbazoles A-C (1-3), from Streptomyces sp. KCB15JA151. Their planar structures were elucidated by detailed NMR and MS spectroscopic analysis with a literature study. Their relative and absolute configurations were established by ROESY correlations, coupling constants, LC-MS analysis of thiocarbamoyl-thiazolidine carboxylate derivatives, and ECD calculation. Compounds 1-3 showed indoleamine 2,3-dioxygenase 1 (IDO1) inhibitory activity with IC50 values of 18.38, 9.17, and 8.81 μM. The molecular docking analysis suggested that all compounds act as heme-displacing inhibitors against IDO1 enzyme.-
dc.publisherRoyal Soc Chem-
dc.titleJejucarbazoles A-C, Carbazole Glycosides with Indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151-
dc.title.alternativeJejucarbazoles A-C, Carbazole Glycosides with Indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151-
dc.typeArticle-
dc.citation.titleRSC Advances-
dc.citation.number0-
dc.citation.endPage19812-
dc.citation.startPage19805-
dc.citation.volume11-
dc.contributor.affiliatedAuthorGil Su Kim-
dc.contributor.affiliatedAuthorJun-Pil Jang-
dc.contributor.affiliatedAuthorMincheol Kwon-
dc.contributor.affiliatedAuthorTae Hoon Oh-
dc.contributor.affiliatedAuthorKyung Taek Heo-
dc.contributor.affiliatedAuthorByeongsan Lee-
dc.contributor.affiliatedAuthorJung-Sook Lee-
dc.contributor.affiliatedAuthorSung-Kyun Ko-
dc.contributor.affiliatedAuthorYoung-Soo Hong-
dc.contributor.affiliatedAuthorJong Seog Ahn-
dc.contributor.affiliatedAuthorJae-Hyuk Jang-
dc.contributor.alternativeName김길수-
dc.contributor.alternativeName장준필-
dc.contributor.alternativeName권민철-
dc.contributor.alternativeName오태훈-
dc.contributor.alternativeName허경택-
dc.contributor.alternativeName이병산-
dc.contributor.alternativeName이정숙-
dc.contributor.alternativeName고성균-
dc.contributor.alternativeName홍영수-
dc.contributor.alternativeName안종석-
dc.contributor.alternativeName장재혁-
dc.identifier.bibliographicCitationRSC Advances, vol. 11, pp. 19805-19812-
dc.identifier.doi10.1039/d1ra02895b-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Biological Resource Center > 1. Journal Articles
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