DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gil Su Kim | - |
dc.contributor.author | Jun-Pil Jang | - |
dc.contributor.author | Mincheol Kwon | - |
dc.contributor.author | Tae Hoon Oh | - |
dc.contributor.author | Kyung Taek Heo | - |
dc.contributor.author | Byeongsan Lee | - |
dc.contributor.author | Jung-Sook Lee | - |
dc.contributor.author | Sung-Kyun Ko | - |
dc.contributor.author | Young-Soo Hong | - |
dc.contributor.author | Jong Seog Ahn | - |
dc.contributor.author | Jae-Hyuk Jang | - |
dc.date.accessioned | 2021-06-03T03:30:34Z | - |
dc.date.available | 2021-06-03T03:30:34Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/24370 | - |
dc.description.abstract | A bioassay-guided investigation led to the isolation of three new carbazole glycosides, jejucarbazoles A-C (1-3), from Streptomyces sp. KCB15JA151. Their planar structures were elucidated by detailed NMR and MS spectroscopic analysis with a literature study. Their relative and absolute configurations were established by ROESY correlations, coupling constants, LC-MS analysis of thiocarbamoyl-thiazolidine carboxylate derivatives, and ECD calculation. Compounds 1-3 showed indoleamine 2,3-dioxygenase 1 (IDO1) inhibitory activity with IC50 values of 18.38, 9.17, and 8.81 μM. The molecular docking analysis suggested that all compounds act as heme-displacing inhibitors against IDO1 enzyme. | - |
dc.publisher | Royal Soc Chem | - |
dc.title | Jejucarbazoles A-C, Carbazole Glycosides with Indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151 | - |
dc.title.alternative | Jejucarbazoles A-C, Carbazole Glycosides with Indoleamine 2,3-dioxygenase 1 inhibitory activity from Streptomyces sp. KCB15JA151 | - |
dc.type | Article | - |
dc.citation.title | RSC Advances | - |
dc.citation.number | 0 | - |
dc.citation.endPage | 19812 | - |
dc.citation.startPage | 19805 | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | Gil Su Kim | - |
dc.contributor.affiliatedAuthor | Jun-Pil Jang | - |
dc.contributor.affiliatedAuthor | Mincheol Kwon | - |
dc.contributor.affiliatedAuthor | Tae Hoon Oh | - |
dc.contributor.affiliatedAuthor | Kyung Taek Heo | - |
dc.contributor.affiliatedAuthor | Byeongsan Lee | - |
dc.contributor.affiliatedAuthor | Jung-Sook Lee | - |
dc.contributor.affiliatedAuthor | Sung-Kyun Ko | - |
dc.contributor.affiliatedAuthor | Young-Soo Hong | - |
dc.contributor.affiliatedAuthor | Jong Seog Ahn | - |
dc.contributor.affiliatedAuthor | Jae-Hyuk Jang | - |
dc.contributor.alternativeName | 김길수 | - |
dc.contributor.alternativeName | 장준필 | - |
dc.contributor.alternativeName | 권민철 | - |
dc.contributor.alternativeName | 오태훈 | - |
dc.contributor.alternativeName | 허경택 | - |
dc.contributor.alternativeName | 이병산 | - |
dc.contributor.alternativeName | 이정숙 | - |
dc.contributor.alternativeName | 고성균 | - |
dc.contributor.alternativeName | 홍영수 | - |
dc.contributor.alternativeName | 안종석 | - |
dc.contributor.alternativeName | 장재혁 | - |
dc.identifier.bibliographicCitation | RSC Advances, vol. 11, pp. 19805-19812 | - |
dc.identifier.doi | 10.1039/d1ra02895b | - |
dc.description.journalClass | Y | - |
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