The development of a functional human small intestinal epithelium model for drug absorption

Cited 0 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorOhman Kwon-
dc.contributor.authorKwang Bo Jung-
dc.contributor.authorKyeong-Ryoon Lee-
dc.contributor.authorYe Seul Son-
dc.contributor.authorHana Lee-
dc.contributor.authorJongjin Kim-
dc.contributor.authorKwangho Kim-
dc.contributor.authorSeop Lee-
dc.contributor.authorYoo-Kyung Song-
dc.contributor.authorJaeeun Jung-
dc.contributor.authorKun Hyang Park-
dc.contributor.authorDae Soo Kim-
dc.contributor.authorMyung Jin Son-
dc.contributor.authorMi Ok Lee-
dc.contributor.authorTae-Su Han-
dc.contributor.authorHyun-Soo Cho-
dc.contributor.authorS J Oh-
dc.contributor.authorH Chung-
dc.contributor.authorS H Kim-
dc.contributor.authorKyung-Sook Chung-
dc.contributor.authorJanghwan Kim-
dc.contributor.authorCho-Rok Jung-
dc.contributor.authorMi-Young Son-
dc.date.accessioned2021-06-05T03:30:23Z-
dc.date.available2021-06-05T03:30:23Z-
dc.date.issued2021-
dc.identifier.issn23752548-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24382-
dc.description.abstractAdvanced technologies are required for generating human intestinal epithelial cells (hIECs) harboring cellular diversity and functionalities to predict oral drug absorption in humans and study normal intestinal epithelial physiology. We developed a reproducible two-step protocol to induce human pluripotent stem cells to differentiate into highly expandable hIEC progenitors and a functional hIEC monolayer exhibiting intestinal molecular features, cell type diversity, and high activities of intestinal transporters and metabolic enzymes such as cytochrome P450 3A4 (CYP3A4). Functional hIECs are more suitable for predicting compounds metabolized by CYP3A4 and absorbed in the intestine than Caco-2 cells. This system is a step toward the transition from three-dimensional (3D) intestinal organoids to 2D hIEC monolayers without compromising cellular diversity and function. A physiologically relevant hIEC model offers a novel platform for creating patient-specific assays and support translational applications, thereby bridging the gap between 3D and 2D culture models of the intestine.-
dc.publisherAmer Assoc Advancement Science-
dc.titleThe development of a functional human small intestinal epithelium model for drug absorption-
dc.title.alternativeThe development of a functional human small intestinal epithelium model for drug absorption-
dc.typeArticle-
dc.citation.titleScience Advances-
dc.citation.number23-
dc.citation.endPageeabh1586-
dc.citation.startPageeabh1586-
dc.citation.volume7-
dc.contributor.affiliatedAuthorOhman Kwon-
dc.contributor.affiliatedAuthorKwang Bo Jung-
dc.contributor.affiliatedAuthorKyeong-Ryoon Lee-
dc.contributor.affiliatedAuthorYe Seul Son-
dc.contributor.affiliatedAuthorHana Lee-
dc.contributor.affiliatedAuthorJongjin Kim-
dc.contributor.affiliatedAuthorKwangho Kim-
dc.contributor.affiliatedAuthorSeop Lee-
dc.contributor.affiliatedAuthorYoo-Kyung Song-
dc.contributor.affiliatedAuthorJaeeun Jung-
dc.contributor.affiliatedAuthorKun Hyang Park-
dc.contributor.affiliatedAuthorDae Soo Kim-
dc.contributor.affiliatedAuthorMyung Jin Son-
dc.contributor.affiliatedAuthorMi Ok Lee-
dc.contributor.affiliatedAuthorTae-Su Han-
dc.contributor.affiliatedAuthorHyun-Soo Cho-
dc.contributor.affiliatedAuthorKyung-Sook Chung-
dc.contributor.affiliatedAuthorJanghwan Kim-
dc.contributor.affiliatedAuthorCho-Rok Jung-
dc.contributor.affiliatedAuthorMi-Young Son-
dc.contributor.alternativeName권오만-
dc.contributor.alternativeName정광보-
dc.contributor.alternativeName이경륜-
dc.contributor.alternativeName손예슬-
dc.contributor.alternativeName이하나-
dc.contributor.alternativeName김종진-
dc.contributor.alternativeName김광호-
dc.contributor.alternativeName이섭-
dc.contributor.alternativeName송유경-
dc.contributor.alternativeName정재은-
dc.contributor.alternativeName박근향-
dc.contributor.alternativeName김대수-
dc.contributor.alternativeName손명진-
dc.contributor.alternativeName이미옥-
dc.contributor.alternativeName한태수-
dc.contributor.alternativeName조현수-
dc.contributor.alternativeName오수진-
dc.contributor.alternativeName정해은-
dc.contributor.alternativeName김상헌-
dc.contributor.alternativeName정경숙-
dc.contributor.alternativeName김장환-
dc.contributor.alternativeName정초록-
dc.contributor.alternativeName손미영-
dc.identifier.bibliographicCitationScience Advances, vol. 7, no. 23, pp. eabh1586-eabh1586-
dc.identifier.doi10.1126/sciadv.abh1586-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
Division of Bio Technology Innovation > Core Facility Management Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
Division of Research on National Challenges > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.