Anti-inflammatory and antioxidant effects of Soroseris hirsuta extract by regulating iNOS/NF-κB and NRF2/HO-1 pathways in murine macrophage RAW 264.7 cells

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dc.contributor.authorW J Lee-
dc.contributor.authorW Y Li-
dc.contributor.authorSang Woo Lee-
dc.contributor.authorS K Jung-
dc.date.accessioned2021-06-16T03:30:28Z-
dc.date.available2021-06-16T03:30:28Z-
dc.date.issued2021-
dc.identifier.issn20763417-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24398-
dc.description.abstractUntil now, the physiological effects of Soroseris hirsuta were primarily unknown. Here we have evaluated the anti-inflammatory and antioxidant effects of Soroseris hirsuta extract (SHE) on lipopolysaccharide (LPS)-activated murine macrophages RAW 264.7 cells. SHE inhibited nitric oxide expression and inducible nitric oxide synthase expression in RAW 264.7 cells treated with LPS. Moreover, SHE suppressed LPS-induced phosphorylation of IκB kinase, inhibitor of kappa B, p65, p38, and c-JUN N-terminal kinase. Western blot and immunofluorescence analyses showed that SHE suppressed p65 nuclear translocation induced by LPS. Furthermore, SHE inhibited the reactive oxygen species in LPS-treated RAW 264.7 cells. SHE significantly increased heme oxygenase-1 expression and the nuclear translocation of nuclear factor erythroid 2-related factor 2. SHE suppressed LPS-induced interleukin-1β mRNA expression in RAW 264.7 cells. Thus, SHE is a promising nutraceutical as it displays anti-inflammatory and antioxidant properties.-
dc.publisherMDPI-
dc.titleAnti-inflammatory and antioxidant effects of Soroseris hirsuta extract by regulating iNOS/NF-κB and NRF2/HO-1 pathways in murine macrophage RAW 264.7 cells-
dc.title.alternativeAnti-inflammatory and antioxidant effects of Soroseris hirsuta extract by regulating iNOS/NF-κB and NRF2/HO-1 pathways in murine macrophage RAW 264.7 cells-
dc.typeArticle-
dc.citation.titleApplied Sciences-Basel-
dc.citation.number10-
dc.citation.endPage4711-
dc.citation.startPage4711-
dc.citation.volume11-
dc.contributor.affiliatedAuthorSang Woo Lee-
dc.contributor.alternativeName이우진-
dc.contributor.alternativeNameLi-
dc.contributor.alternativeName이상우-
dc.contributor.alternativeName정성근-
dc.identifier.bibliographicCitationApplied Sciences-Basel, vol. 11, no. 10, pp. 4711-4711-
dc.identifier.doi10.3390/app11104711-
dc.subject.keywordSoroseris hirsuta-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordAntioxidant-
dc.subject.keywordNitric oxide-
dc.subject.keywordHeme oxygenase-1-
dc.subject.localAnti-inflammation-
dc.subject.localAntioxidant-
dc.subject.localNitric oxide-
dc.subject.localNitric oxide (NO)-
dc.subject.localHeme oxygenase-1-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > International Biological Material Research Center > 1. Journal Articles
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