Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of Transferrin receptor

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dc.contributor.authorSeong Heon Kim-
dc.contributor.authorJin Hwa Cho-
dc.contributor.authorBi-Oh Park-
dc.contributor.authorByoung Chul Park-
dc.contributor.authorJeong Hoon Kim-
dc.contributor.authorSung Goo Park-
dc.contributor.authorSunhong Kim-
dc.date.accessioned2021-06-16T03:30:31Z-
dc.date.available2021-06-16T03:30:31Z-
dc.date.issued2021-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24399-
dc.description.abstractRalBP1 associated EPS domain containing 1 (REPS1) is conserved from Drosophila to humans and implicated in the endocytic system. However, an exact role of REPS1 remains largely unknown. Here, we demonstrated that mitogen activated protein kinase kinase (MEK)-p90 ribosomal S6 Kinase (RSK) signaling pathway directly phosphorylated REPS1 at Ser709 upon stimulation by epidermal growth factor (EGF) and amino acid. While REPS2 is known to be involved in the endocytosis of EGF receptor (EGFR), REPS1 knockout (KO) cells did not show any defect in the endocytosis of EGFR. However, in the REPS1 KO cells and the KO cells reconstituted with a non-phosphorylatable REPS1 (REPS1 S709A), the recycling of transferrin receptor (TfR) was attenuated compared to the cells reconstituted with wild type REPS1. Collectively, we suggested that the phosphorylation of REPS1 at S709 by RSK may have a role of the trafficking of TfR.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titlePhosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of Transferrin receptor-
dc.title.alternativePhosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of Transferrin receptor-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number5-
dc.citation.endPage277-
dc.citation.startPage272-
dc.citation.volume54-
dc.contributor.affiliatedAuthorSeong Heon Kim-
dc.contributor.affiliatedAuthorJin Hwa Cho-
dc.contributor.affiliatedAuthorBi-Oh Park-
dc.contributor.affiliatedAuthorByoung Chul Park-
dc.contributor.affiliatedAuthorJeong Hoon Kim-
dc.contributor.affiliatedAuthorSung Goo Park-
dc.contributor.affiliatedAuthorSunhong Kim-
dc.contributor.alternativeName김성헌-
dc.contributor.alternativeName조진화-
dc.contributor.alternativeName박비오-
dc.contributor.alternativeName박병철-
dc.contributor.alternativeName김정훈-
dc.contributor.alternativeName박성구-
dc.contributor.alternativeName김선홍-
dc.identifier.bibliographicCitationBMB Reports, vol. 54, no. 5, pp. 272-277-
dc.identifier.doi10.5483/bmbrep.2021.54.5.266-
dc.subject.keywordAttenuation-
dc.subject.keywordPhosphorylation-
dc.subject.keywordRecycling-
dc.subject.keywordRSK-
dc.subject.keywordTransferrin receptor-
dc.subject.localAttenuation-
dc.subject.localPhosphorylation-
dc.subject.localphosphorylation-
dc.subject.localRecycling-
dc.subject.localRSK-
dc.subject.localtransferrin receptor-
dc.subject.localTransferrin receptor-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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