Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

Cited 3 time in scopus
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Title
Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids
Author(s)
A Marsee; F J M Roos; M M A Verstegen; HPB Organoid Consortium; H Gehart; E Koning; F Lemaigre; S J Forbes; W C Peng; M Huch; T Takebe; L Vallier; H Clevers; L J W Laan; B Spee; Seonju Mun; Myung Jin Son
Bibliographic Citation
Cell Stem Cell, vol. 28, no. 5, pp. 816-832
Publication Year
2021
Abstract
Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development, disease, and regeneration. As organoid research expands, the need for clear definitions and nomenclature describing these systems also grows. To facilitate scientific communication and consistent interpretation, we revisit the concept of an organoid and introduce an intuitive classification system and nomenclature for describing these 3D structures through the consensus of experts in the field. To promote the standardization and validation of HPB organoids, we propose guidelines for establishing, characterizing, and benchmarking future systems. Finally, we address some of the major challenges to the clinical application of organoids.
ISSN
1934-5909
Publisher
Elsevier-Cell Press
DOI
http://dx.doi.org/10.1016/j.stem.2021.04.005
Type
Article
Appears in Collections:
Division of Research on National Challenges > Stem Cell Convergenece Research Center > 1. Journal Articles
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