The human TOR signaling regulator is the key indicator of liver cancer patients' overall survival: TIPRL/LC3/CD133/CD44 as potential biomarkers for early liver cancers

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Title
The human TOR signaling regulator is the key indicator of liver cancer patients' overall survival: TIPRL/LC3/CD133/CD44 as potential biomarkers for early liver cancers
Author(s)
Soo Young Jun; Hyang Ran YoonJi Yong Yoon; Su Jin Jeon; Jeong Ju Lee; D Halder; J M Kim; Nam-Soon Kim
Bibliographic Citation
Cancers, vol. 13, no. 12, pp. 2925-2925
Publication Year
2021
Abstract
Recently, we reported the involvement of TIPRL/LC3/CD133 in liver cancer aggressive-ness. This study assessed the human TOR signaling regulator (TIPRL)/microtubule-associated light chain 3 (LC3)/prominin-1 (CD133)/cluster of differentiation 44 (CD44) as potential diagnostic and prognostic biomarkers for early liver cancer. For the assessment, we stained tissues of human liver disease/cancer with antibodies against TIPRL/LC3/CD133/CD44/CD46, followed by con-focal observation. The roles of TIPRL/LC3/CD133/CD44/CD46 in liver normal and cancer cell lines were determined by in vitro studies. We analyzed the prognostic and diagnostic potentials of TIPRL/LC3/CD133/CD44/CD46 using the receiver-operating characteristic curve, a Kaplan?Meier and uni-/multi-Cox analyses. TIPRL and LC3 were upregulated in tissues of HCCs and adult hepatocytes-derived liver diseases while downregulated in iCCA. Intriguingly, TIPRL levels were found to be critically associated with liver cancer patients’ survivability, and TIPRL is the key player in liver cancer cell proliferation and viability via stemness and self-renewal induction. Further-more, we demonstrate that TIPRL/LC3/CD133 have shown prominent efficiency for diagnosing patients with grade 1 iCCA. TIPRL/LC3/CD133/CD44 have also provided excellent potential for prognosticating patients with grade 1 iCCA and grade 1 HCCs, together with demonstrating that TIPRL/LC3/CD133/CD44 are, either individually or in conjunction, potential biomarkers for early liver cancer. ⓒ 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keyword
Liver cancerHuman TOR signaling regulator (TIPRL)Microtubule-associated light chain 3 (LC3)Prominin-1 (CD133)Cluster of differentiation 44 (CD44)Receiver-operating characteristic (ROC) curveKaplan?Meier analysisUni-/multi-Cox analyseshepatocellular carcinomas (HCCs)Intrahepatic carcinomas (iCCA)
ISSN
2072-6694
Publisher
MDPI
DOI
http://dx.doi.org/10.3390/cancers13122925
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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