Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism

Cited 12 time in scopus
Metadata Downloads

Full metadata record

DC FieldValueLanguage
dc.contributor.authorYoung-Kyoung Ryu-
dc.contributor.authorHey-Yeon Park-
dc.contributor.authorJun Go-
dc.contributor.authorDong Hee Choi-
dc.contributor.authorYoung Keun Choi-
dc.contributor.authorM Rhee-
dc.contributor.authorChul-Ho Lee-
dc.contributor.authorKyoung Shim Kim-
dc.date.accessioned2021-07-01T03:31:35Z-
dc.date.available2021-07-01T03:31:35Z-
dc.date.issued2021-
dc.identifier.issn0033-3158-
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/24442-
dc.description.abstractAutism spectrum disorder (ASD) is a neurodevelopment disorder characterized by deficits in social interaction and restrictive, repetitive, and stereotypical patterns of behavior. However, there is no pharmacological drug that is currently used to target these core ASD symptoms. Sodium phenylbutyrate (NaPB) is a well-known long-term treatment of urea cycle disorders in children. In this study, we assessed the therapeutic effects of NaPB, which is a chemical chaperone as well as histone deacetylase inhibitor on a BTBR T + Itpr3tf/J (BTBR) mice model of ASD. We found that acute and chronic treatment of NaPB remarkably improved, not only core ASD symptoms, including repetitive behaviors and sociability deficit, but also cognitive impairment in the BTBR mice. NaPB substantially induced histone acetylation in the brain of the BTBR mice. Intriguingly, the therapeutic effects of NaPB on autistic-like behaviors, such as repetitive behaviors, impaired sociability, and cognitive deficit also showed in the valproic acid (VPA)-induced mouse model of autism. In addition, pentylenetetrazole (PTZ)-induced seizure was significantly attenuated by NaPB treatment in C57BL/6J and BTBR mice. These findings suggest that NaPB may provide a novel therapeutic approach for the treatment of patients with ASD.-
dc.publisherSpringer-
dc.titleSodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism-
dc.title.alternativeSodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism-
dc.typeArticle-
dc.citation.titlePsychopharmacology-
dc.citation.number7-
dc.citation.endPage1845-
dc.citation.startPage1833-
dc.citation.volume238-
dc.contributor.affiliatedAuthorYoung-Kyoung Ryu-
dc.contributor.affiliatedAuthorHey-Yeon Park-
dc.contributor.affiliatedAuthorJun Go-
dc.contributor.affiliatedAuthorDong Hee Choi-
dc.contributor.affiliatedAuthorYoung Keun Choi-
dc.contributor.affiliatedAuthorChul-Ho Lee-
dc.contributor.affiliatedAuthorKyoung Shim Kim-
dc.contributor.alternativeName유영경-
dc.contributor.alternativeName박혜연-
dc.contributor.alternativeName고준-
dc.contributor.alternativeName최동희-
dc.contributor.alternativeName최영근-
dc.contributor.alternativeName이명철-
dc.contributor.alternativeName이철호-
dc.contributor.alternativeName김경심-
dc.identifier.bibliographicCitationPsychopharmacology, vol. 238, no. 7, pp. 1833-1845-
dc.identifier.doi10.1007/s00213-021-05812-z-
dc.subject.keywordAutism spectrum disorder-
dc.subject.keywordSodium phenylbutyrate-
dc.subject.keywordSocial interaction-
dc.subject.keywordCognition-
dc.subject.keywordRepetitive behavior-
dc.subject.localAutism spectrum disorders-
dc.subject.localAutism spectrum disorder (ASD)-
dc.subject.localAutism spectrum disorder-
dc.subject.localSodium phenylbutyrate-
dc.subject.localSocial interaction-
dc.subject.localCognition-
dc.subject.localRepetitive behavior-
dc.description.journalClassY-
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > Laboratory Animal Resource & Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.