Receptor-mediated muscle homeostasis as a target for sarcopenia therapeutics

Cited 0 time in scopus
Metadata Downloads
Title
Receptor-mediated muscle homeostasis as a target for sarcopenia therapeutics
Author(s)
Jong Hyeon Yoon; Ki-Sun Kwon
Bibliographic Citation
Endocrinology and Metabolism, vol. 36, no. 3, pp. 478-490
Publication Year
2021
Abstract
Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement of multiple interconnected signaling pathways. Therefore, signaling receptors are major targets in pharmacological strategies in general. To provide a rationale for pharmacological interventions for sarcopenia, we herein describe several druggable signaling receptors based on their role in skeletal muscle homeostasis and changes in their activity with aging. A brief overview is presented of the efficacy of corresponding drug candidates under clinical trials. Strategies targeting the androgen receptor, vitamin D receptor, Insulin-like growth factor-1 receptor, and ghrelin receptor primarily focus on promoting anabolic action using natural ligands or mimetics. Strategies involving activin receptors and angiotensin receptors focus on inhibiting catabolic action. This review may help to select specific targets or combinations of targets in the future.
Keyword
SarcopeniaMuscle, skeletalAgingDrug therapyReceptors, cell surfaceReceptors, cytoplasmic and nuclearSignal transductionMolecular mechanisms of pharmacological actionClinical trial
ISSN
2093-596X
DOI
http://dx.doi.org/10.3803/EnM.2021.1081
Type
Article
Appears in Collections:
Division of Research on National Challenges > Aging Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.